Antifungal activity of Pelargonium graveolens essential oils from different geographical locations against Candida albicans

  • Mohaddese Mahboubi Department of Microbiology, Medicinal Plant, Research Center of Barij, Kashan, Iran
  • Mehdi Mehran Department of Phytochemistry, Medicinal Plant, Research Center of Barij, Kashan, Iran
  • Hossein Hosseini Department of Agriculture, Medicinal Plant, Research Center of Barij, Kashan, Iran
Keywords: Candida albicans, Citronellol, Geraniol, Geographical location, Pelargonium graveolens

Abstract

Vulvovaginal candidiasis, an acute inflammatory disease, is caused by Candida sp. especially C. albicans. The antifungal activity was studied using micro-broth dilution assay of 16 samples of P. graveolens essential oils from different geographical locations (Germany, n = 5; India, n = 3; Iran, n = 8) and different combinations of geraniol and citronellol (10:90; 20:80; 30:70; 40:60; 5:50; 60:40; 7:30; 80:20; 90:10; 95:5, respectively) against 72 clinical isolates of C. albicans from vaginal discharges. All nine combinations of geraniol and citronellol tested had the same anti-candidal effects against C. albicans. P. graveolens essential oil E20 (geraniol, 95%), and E9 (citronellol, 48%; geraniol, 5.1%; citronellol fromate, 16.2%) had minimal inhibitory concentration values (means ± Standard Deviation) of 0.497 ± 0.085 and 1.149 ± 0.083 μL/mL, respectively. Although geraniol and citronellol played an important role in the anti-candidal activity of P. graveolens essential oils, other minor components may also have roles in its anti-candidal activity.

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Published
2019-04-30
Section
Research Article