Antifungal activity of Pelargonium graveolens essential oils from different geographical locations against Candida albicans

Authors

  • Mohaddese Mahboubi Department of Microbiology, Medicinal Plant, Research Center of Barij, Kashan, Iran
  • Mehdi Mehran Department of Phytochemistry, Medicinal Plant, Research Center of Barij, Kashan, Iran
  • Hossein Hosseini Department of Agriculture, Medicinal Plant, Research Center of Barij, Kashan, Iran

Keywords:

Candida albicans, Citronellol, Geraniol, Geographical location, Pelargonium graveolens

Abstract

Vulvovaginal candidiasis, an acute inflammatory disease, is caused by Candida sp. especially C. albicans. The antifungal activity was studied using micro-broth dilution assay of 16 samples of P. graveolens essential oils from different geographical locations (Germany, n = 5; India, n = 3; Iran, n = 8) and different combinations of geraniol and citronellol (10:90; 20:80; 30:70; 40:60; 5:50; 60:40; 7:30; 80:20; 90:10; 95:5, respectively) against 72 clinical isolates of C. albicans from vaginal discharges. All nine combinations of geraniol and citronellol tested had the same anti-candidal effects against C. albicans. P. graveolens essential oil E20 (geraniol, 95%), and E9 (citronellol, 48%; geraniol, 5.1%; citronellol fromate, 16.2%) had minimal inhibitory concentration values (means ± Standard Deviation) of 0.497 ± 0.085 and 1.149 ± 0.083 μL/mL, respectively. Although geraniol and citronellol played an important role in the anti-candidal activity of P. graveolens essential oils, other minor components may also have roles in its anti-candidal activity.

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Published

2019-04-30

How to Cite

Mahboubi, Mohaddese, Mehdi Mehran, and Hossein Hosseini. 2019. “Antifungal Activity of Pelargonium Graveolens Essential Oils from Different Geographical Locations Against Candida Albicans”. Agriculture and Natural Resources 53 (2). Bangkok, Thailand:148-53. https://li01.tci-thaijo.org/index.php/anres/article/view/229920.

Issue

Section

Research Article