The Study of Sulfathiazole in Catfish (Pangasius Pangasius) Following the Intravenous, Intramuscular and Oral Drug Administration

Abstract

The disposition of sulfathiazole was studied in catfish (Pangasius pangasius) following the intravenous, intramuscular and oral drug administration. The drug was administered as 15% solution of sulfathiazole at the dosage of 66 mg/kg body weight. The blood samples were collected via the caudal blood vessels. The plasma concentrations of the drug and acetyl metabolite were analysed. Following intravenous administration of sulfathiazole, minimum effective concentrations of the drug were maintained for at least 24 hours. The drug was completely excreted within 96 hours. The drug was completely absorbed following ir~tramusculara dministration but incompletely absorbed following oral dosing. The bioavailability following intramuscular and oral administration were 1C)O% and 17.4%, respectively. The biphasic shape of the plasma disappearance curve suggested that a two compartment model would be used to describe the pharmacokinetic behavior of the drug in catfish.