Study on Sulfadimethylpyrimidine in Pangasius pangasius Following the Intravenous, Intramuscular and Oral Drug Administration

Abstract

The disposition of sulfadimethylpyrimidine was studied in Pangasius pangasius following the intravenous, intramuscular and oral drug dosing. The drug was administered as 25% solution at the dosage of 107.25 mglkg. Blood samples were collected via the caudal blood vessels at specific times and determined by the Direct and Total method of Bratton and Marshall. The drug was incompletely absorbed following intramuscular and oral administration. The bioavailability were 69.02% and 12.36% following the intramuscular and oral dosing, respectively. The Three Compartment Model would be used to describe the disposition of the drug in Pangasius pangasius. Estimation of all the rate constant was also obtained.