Study of Sulfamonomethoxine in Catfish (Pangasius pangasius) Following the Intravenous, Intramuscular and Oral Drug Administration

Abstract

The disposition of sulfamonomethoxine was studied in Pangasius pangasius following the intravenous, intramuscular and oral drug administration. The drug was administered as 20% solution at the dosage of 200 mg/kg. body weight. Blood samples were collected at specific times via the caudal blood vessels and determined by the Direct and Total method of Bratton and Marshall. Following intravenous administration, the drug was excreted within 108 hours. The maximum plasma concentration reached 32.72 mg % and 28.4 mg % following the intravenous and intramuscular dosing and maintained above 5 mg % for 24 hours. The drug was incompletely absorbed after oral administration. Approximately 70.57% and 16.63% of the given dose were absorbed following intramuscular and oral administration, respectively. The biphasic shape of the plasma disappearance curve suggested that a two compartment model would be used to describe the behavior of the drug in catfish.