Inhibition Effect of Antimicrobial Drugs on Growth of Aeromonas hydrophila in Pla Duk Dan (Clarias batrachus Linn.)

Abstract

This experiment was designed to study the inhibiting effect of chloramphenicol, sulfamonomethoxine, doxycycline and furazolidone on growth of Aeromonas hydrophila in Pla Duk Dan (Clarias batrachus Linn.). It was found that a single intramuscular administration of chloramphenicol and sulfamonomethoxine at concentrations of 50 and 200 milligrams per kilogram of fish body weight, would respectively give very good suppression effect on multiplication of the bacteria. The number of bacteria in blood circulation dropped rapidly when compared between drugs and non-drugs administered groups of fish starting at 1 hour and remained in relative low number for twelve hours after drugs administration. Results from the same experiments also indicated that there was a better effect of sulfamonomethoxine than chloramphenicol on the bacterial growth inhibition. Chloramphenicol and sulfamonomethoxine were both less effective on bacterial growth inhibition when they were given orally using the same doses with the intramuscular route. The better effect, however, would be attained when the second does was given at eight hours after the first administration. Results obtained from oral administration of furazolidone and doxycycline at concentrations of 10 and 40 milligrams per fish body weight respectively indicated the fairly good suppression effect on growth of bacteria though it took longer lag period and shorter inhibiting duration than those of sulfamonomethoxine and chloramphenicol.