Isolation of Anti-malarial Active Compound from Yanang (Tiliacora triandra Diels)

Authors

  • Chalerm Saiin Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.
  • Sutthatip Markmee Department of Pharmaceutical Chemistry and Pharmacognosy, Faculty of Pharmaceutical Sciences, Naresuan University, Phitsanulok 65000, Thailand.

Keywords:

anti-malarial, Yanang, Tiliacora triandra Diels, tiliacorinine, tiliacorine

Abstract

Malaria remains to be one of the serious problems in tropical countries because of the increase in antimalarial drug resistance. This investigation was to study the extraction of bioactive compounds with anti-malarial activity from Yanang (Tiliacora triandra Diels) root. The dried root was extracted with chloroform : methanol : ammonium hydroxide mixture (50:50:1). Further isolation and purification of the crude extract using column chromatography and crystallization techniques provided two pure alkaloid compounds: tiliacorinine (I) and tiliacorine (II) with 0.0082 and 0.0029 percent yield, respectively. Structures of I and II were confirmed by spectroscopy techniques and compared with reference data.

Downloads

Published

2003-03-31

How to Cite

Chalerm Saiin, and Sutthatip Markmee. 2003. “Isolation of Anti-Malarial Active Compound from Yanang (Tiliacora Triandra Diels)”. Agriculture and Natural Resources 37 (1). Bangkok, Thailand:47-51. https://li01.tci-thaijo.org/index.php/anres/article/view/242785.

Issue

Vol. 37 No. 1 (2003): January-March

Section

Research Article

License

online 2452-316X print 2468-1458/Copyright © 2022. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/),
production and hosting by Kasetsart University of Research and Development Institute on behalf of Kasetsart University.