Development of Mangosteen Anti-Acne Gel

Abstract

The ethanolic fruit peel extracts from mangosteen (Garcinia mangostana L.) which is widely grown in the east and the south of Thailand have potential for inhibiting acne - causing bacteria. The purpose of the present study was to develop mangosteen anti-acne gel by using 3² factorial design. The result showed that the optimal formula of anti-acne gel with mangosteen crude extract contained water, Carbopol Ultrez-10, Triethanolamine, Panthenol, Dimethicone, Germaben II, Polysorbate 20 and mangosteen crude extract 94.2%, 0.5%, 0.5%, 0.5%, 2.0%, 0.8%, 1.0 % and 0.5%, respectively. Antiacne gel with mangosteen crude extract was yellowish brown in color with L*, a* and b* 31.39, 2.19 and 4.49, respectively. The gel pH was 6.07 and its viscosity was 8023.33 cP. The mangosteen anti-acne gel was satisfactorily effective to control acne inducing bacteria; Staphylococcus aureus, S. epidermidis and Propionibacterium acnes. In addition, the consumer acceptance test with 120 targeted consumers showed that 71.7 % of them accepted the gel and the overall liking was a little like.