Antimutagenicity and Anti-HSV-2 Activity of Mulberry Tea (Morus rotunbiloba Koidz)

Authors

  • Thipamon Patharakorn Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.
  • Sulak Talawat Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.
  • Amornrat Promboon Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.
  • Nuanchawee Wetprasit Department of Biotechnology, Faculty of Science, Ramkhamhaeng University, Bangkok 10900, Thailand.
  • Sunanta Ratanapo Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.

Keywords:

mulberry tea, Morus rotunbiloba, antimutagenicity, anti-HSV-2

Abstract

Hot water extract from mulberry leaves, Morus rotunbiloba Koidz was extracted with diethyl ether, and its components were analyzed using high-pressure liquid chromatography (HPLC). Polyphenolic compounds constituted the major component (79.8%), consisting of mainly tannic acid
(37.9%), epigallocatechin-3-gallate (21.1%) and caffeic acid (11.2%). The genotoxicity of the extract was evaluated by the Ames mutagenicity test, using Salmonella typhimurium strain TA 98 induced by a mutagen Trp-P-1. It was found that the number of revertant colonies was significantly decreased with an IC50 value of 4.5 mg/mL. The extract of Morus rotunbiloba Koidz also exhibited marked antiviral activity against herpes simplex virus type 2 (HSV-2) with an IC50 of 0.52 μg/mL. The results suggested  the benefit of consumption of mulberry tea for prevention of cancer and HSV-2 infection.

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Published

2010-10-30

How to Cite

Thipamon Patharakorn, Sulak Talawat, Amornrat Promboon, Nuanchawee Wetprasit, and Sunanta Ratanapo. 2010. “Antimutagenicity and Anti-HSV-2 Activity of Mulberry Tea (Morus Rotunbiloba Koidz)”. Agriculture and Natural Resources 44 (5). Bangkok, Thailand:816-23. https://li01.tci-thaijo.org/index.php/anres/article/view/244994.

Issue

Vol. 44 No. 5 (2010): September-October

Section

Research Article

License

online 2452-316X print 2468-1458/Copyright © 2022. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/),
production and hosting by Kasetsart University of Research and Development Institute on behalf of Kasetsart University.