The Effect of Pedilanthus tithymaloides (L.) Poit Crude Extract on Wound Healing Stimulation in Mice

Authors

  • Waroonluk Sriwiroch Department of Anatomy, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
  • Narong Chungsamarnyart Department of Anatomy, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
  • Sirirak Chantakru Department of Anatomy, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
  • Pakawadee Pongket Department of Anatomy, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
  • Krisana Saengprapaitip Department of Anatomy, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
  • Urai Pongchairerk Department of Anatomy, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.

Keywords:

Pedilanthus tithymaloides, wound healing, excision wounds, ethanolic crude extract, mouse

Abstract

The study aimed to investigate the potential of an ethanolic extract of Pedilanthus tithymaloides to stimulate excision wound healing. Samples of 42 female mice were divided into three groups: group I – methylcellulose (negative control); group II – 0.5% (w/w) crude extract; and group III – 1.5% (w/w) crude extract. The results were compared among treatments and a control group, in terms of wound appearance, parameters of wound healing and a histopathological study. In the treatment groups, the parameters of wound healing were significantly (P < 0.05) higher in comparison with the control group. The histopathological study also showed increased fibroblast, collagen fiber and blood vessel formation. However, the wounds treated by 0.5% crude extract healed faster when compared to the group with 1.5% crude extract. In conclusion, 0.5% crude extract of P.tithymaloides was more suitable for the stimulation of wound healing than 1.5% crude extract because the latter was too concentrated that caused irritation and inflammation, leading to delayed healing. 

Downloads

Published

2010-12-30

How to Cite

Waroonluk Sriwiroch, Narong Chungsamarnyart, Sirirak Chantakru, Pakawadee Pongket, Krisana Saengprapaitip, and Urai Pongchairerk. 2010. “The Effect of Pedilanthus Tithymaloides (L.) Poit Crude Extract on Wound Healing Stimulation in Mice”. Agriculture and Natural Resources 44 (6). Bangkok, Thailand:1121-27. https://li01.tci-thaijo.org/index.php/anres/article/view/245093.

Issue

Vol. 44 No. 6 (2010): November-December

Section

Research Article

License

online 2452-316X print 2468-1458/Copyright © 2022. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/),
production and hosting by Kasetsart University of Research and Development Institute on behalf of Kasetsart University.