Biochemical Alterations and Their Relationships with the Metabolic Syndrome Components in Canine Obesity

Authors

  • Tippayaporn Tribuddharatana Veterinary Teaching Hospital, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.
  • Yuwadee Kongpiromchean Division of Animal Health Science, Faculty of Agriculture Bangpra, Rajamankala University of Technology Tawanok, Chon Buri 20110, Thailand.
  • Kosit Sribhen Department of Clinical Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
  • Choosri Sribhen Department of Physiology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.

Keywords:

biochemical alteration, relationship, metabolic syndrome, canine obesity

Abstract

Metabolic changes accompanying obesity have been intensively studied in humans but are rarely reported in animals. The present study aimed to investigate alterations of glucose metabolism and biochemical parameters in renal, lipid and liver profiles and to study their metabolic relationship
determined in 31 obese dogs compared with 31 non-obese control dogs. The results showed that with the exception of creatinine and aspartate aminotransferase, all other parameters measured in obese animals exhibited significantly higher levels than those in the control group. In contrast to non-obese dogs, significant associations of glucose with several lipid parameters and liver enzymes alanine aminotransferase (ALT) and gamma-glutamyltransferase (GGT) were observed in obese dogs. These enzymes, on the other hand, displayed significant correlations with total cholesterol and low-density lipoprotein cholesterol, but not with high-density lipoprotein cholesterol. The results indicated that ALT and GGT may have major pathophysiological roles in obesity-related metabolic alterations and should be included as biochemical criteria of metabolic syndrome in canine obesity. 

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Published

2011-08-30

How to Cite

Tippayaporn Tribuddharatana, Yuwadee Kongpiromchean, Kosit Sribhen, and Choosri Sribhen. 2011. “Biochemical Alterations and Their Relationships With the Metabolic Syndrome Components in Canine Obesity”. Agriculture and Natural Resources 45 (4). Bangkok, Thailand:622-28. https://li01.tci-thaijo.org/index.php/anres/article/view/245340.

Issue

Vol. 45 No. 4 (2011): July-August

Section

Research Article

License

online 2452-316X print 2468-1458/Copyright © 2022. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/),
production and hosting by Kasetsart University of Research and Development Institute on behalf of Kasetsart University.