Antioxidant and anti-aging enzyme activities of bioactive compounds isolated from selected Zingiberaceae plants

Authors

  • Rittipun Rungruang Department of Cosmetic Science, Faculty of Science and Technology, Suan Dusit University, Bangkok 10700, Thailand
  • Wittawat Ratanathavorn Department of Cosmetic Science, Faculty of Science and Technology, Suan Dusit University, Bangkok 10700, Thailand
  • Nattaporn Boohuad Department of Cosmetic Science, Faculty of Science and Technology, Suan Dusit University, Bangkok 10700, Thailand
  • Orrapun Selamassakul Pilot Plant Development and Training Institute, King Mongkut’s University of Technology Thonburi, (Bangkhuntien campus) Bangkok 10150, Thailand
  • Nattapon Kaisangsri Pilot Plant Development and Training Institute, King Mongkut’s University of Technology Thonburi, (Bangkhuntien campus) Bangkok 10150, Thailand

Keywords:

anti-aging enzyme activities, antioxidant activity, curcuminoid, cytotoxicity, Zingiberaceae plants

Abstract

Bioactive compounds and antioxidant and enzyme inhibition activity levels were evaluated for three plants in the Zingiberaceae family in Thailand. Quantification of the phenolic and curcumin contents revealed that the largest component of all extracts was phenolic compounds (213.16–317.64 mg/g extract). The major curcuminoids in Curcuma longa L., Curcuma aromatica Salisb. and Zingiber montanum (J.Koenig) Link ex A.Dietr. were bisdemethoxycurcumin (BDMC; 27.31 mg/g extract), curcumin (16.59 mg/g extract), and curcumin (0.12 mg/g extract), respectively. The extracts from C. longa, C. aromatica and Z. montanum all showed antioxidant activity that was assessed using 1,1-diphenyl-2-picrylhydrazyl radical 2,2-diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl (DPPH•) and 2,2’-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS•+) radical scavenging assay. In addition, all extracts had copper chelating activity of more than 50%, with the extract from C. longa having the highest chelating activity (76.45%). All extracts from the three plants inhibited tyrosinase and elastase activity with half maximal inhibitory concentration values of 290.33–1,373.68 μg/mL and 69.61–3386.23 μg/mL, respectively. In addition, collagenase inhibition activity was observed in all extracts. The findings from this study showed that extracts from C. longa, C. aromatica and Z. montanum have potential antioxidant activity and can act as anti-tyrosinase, anti-collagenase and anti-elastase agents. The extracts could be further applied in cosmeceuticals as an active ingredient for anti-aging products.

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Published

2021-01-31

Issue

Section

Research Article