Biological activities and genome of marine Streptomyces verrucosisporus CPB1-1T

Authors

  • Wongsakorn Phongsopitanun Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
  • Pawina Kanchanasin Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
  • Paranee Sripreechasak Department of Biotechnology, Faculty of Science, Burapha University, Chon Buri 20131, Thailand
  • Pattama Pittayakhajonwut National Center for Genetic Engineering and Biotechnology (BIOTEC), Thailand Science Park, Pathum Thani 12120, Thailand
  • Somboon Tanasupawat Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand

Keywords:

Biological activity, Marine actinobacteria, Secondary metabolites, Streptomyces verrucosisporus

Abstract

The CPB1-1T strain of Streptomyces verrucosisporus has been isolated from marine sediment in Thailand. The objective of this study was to determine for the first time the biological activity and to obtain the genome sequence of this type strain. The crude ethyl acetate extract of the type strain had potent antibacterial activity against Gram-positive bacteria (Bacillus cereus and Enterococcus faecium) with a minimum inhibitory concentration (MIC) of 1.56 μg/mL. In addition, it showed anti-Mycobacterium tuberculosis activity with a MIC value of 6.25 μg/mL. The crude extract had no activity against the Gram-negative bacteria Plasmodium falciparum, nor cancer cell lines. The genome analysis revealed that the strain CPB1-1T had several biosynthetic gene clusters of secondary metabolites including terpene, polyketide, lanthipeptide, lasso peptide and thiopeptide.

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Published

2021-04-09

How to Cite

Wongsakorn Phongsopitanun, Pawina Kanchanasin, Paranee Sripreechasak, Pattama Pittayakhajonwut, and Somboon Tanasupawat. 2021. “Biological Activities and Genome of Marine Streptomyces Verrucosisporus CPB1-1T”. Agriculture and Natural Resources 55 (2). Bangkok, Thailand:209–212. https://li01.tci-thaijo.org/index.php/anres/article/view/251031.

Issue

Section

Short Communication