Effects of crocodile (Crocodylus siamensis) oil and palm oil on leptin-activated signal transducer and activator of transcription 3 signaling pathway and hepatic fat accumulation in rats

Authors

  • Pitchaya Santativongchai Bio-Veterinary Sciences (International Program), Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand
  • Krittika Srisuksai Department of Zoology, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand
  • Kongphop Parunyakul Department of Zoology, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand
  • Paweena Aendo Department of Veterinary Public Health, Faculty of Veterinary Medicine, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom 73140, Thailand
  • Urai Pongchairerk Department of Anatomy, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand
  • Prapassorn Boonsoongnern Department of Anatomy, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand
  • Wirasak Fungfuang Department of Zoology, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand
  • Phitsanu Tulayakul Department of Veterinary Public Health, Faculty of Veterinary Medicine, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom 73140, Thailand

Keywords:

Crocodile oil, Leptin, Neuropeptide Y (NPY), Palm oil, Signal transducer and activator of transcription 3 (STAT3)

Abstract

Importance of the work: Although fat is an essential nutrient, its accumulation is associated with chronic diseases in animals and humans. Different types of oil differently alter food intake and energy expenditure through regulation of leptin signaling.
Objectives: To investigate the effect of palm oil (PO) and crocodile oil (CO) consumption on leptin signaling in rats.
Materials & Methods: Male Wistar rats (7 rats/group) were divided into control, PO and CO groups. The rats were treated with the oils or water (control) supplied using oral gavage once daily (3 mL per kg body weight) for 7 wk.
Results: The CO group had significantly (p < 0.01) lower food intake than the control group. The calculated total area of fat droplets in the liver tissues of the CO group was significantly (p < 0.01) lower than for the PO group. The increased phosphorylation of the signal transducer and activator of transcription 3 accompanied by hunger suppression with the attenuation of Neuropeptide Y expression was higher in the CO group.
Main finding: CO lowered hunger expression and hepatic fat accumulation due to the increased promotion of leptin sensitivity compared to PO. Further study should investigate CO consumption in other animals for further alternative uses in medical therapy.

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Published

2023-06-30

How to Cite

Santativongchai, Pitchaya, Krittika Srisuksai, Kongphop Parunyakul, Paweena Aendo, Urai Pongchairerk, Prapassorn Boonsoongnern, Wirasak Fungfuang, and Phitsanu Tulayakul. 2023. “Effects of Crocodile (Crocodylus Siamensis) Oil and Palm Oil on Leptin-Activated Signal Transducer and Activator of Transcription 3 Signaling Pathway and Hepatic Fat Accumulation in Rats”. Agriculture and Natural Resources 57 (3). Bangkok, Thailand:461–468. https://li01.tci-thaijo.org/index.php/anres/article/view/260136.

Issue

Vol. 57 No. 3 (2023): May-June

Section

Research Article

License

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