Antioxidant properties and encapsulation methods of astaxanthin: A review

Authors

  • Dr.Kitisart Kraboun Rajamangala University of Technology

Keywords:

Bioavailability, antioxidant, encapsulation, astaxanthin

Abstract

Astaxanthin is a predominant carotenoid pigment and a highly efficient antioxidant affecting health benefits. It is primarily found in algae or bacterium organisms and is a kind of natural colorants found in marine organisms, including hard-shelled-aquatic animals such as crabs and shrimp, and fish such as salmon and sea bream. Astaxanthin comprises the conjugated double bonds within its structure, which lead to a cause of rising the activation energy from the singlet oxygen; therefore, the singlet oxygen is destroyed by auto-oxidation mechanism.
This demonstrates higher antioxidative capacity of astaxanthin compared with
β-carotene and vitamin E. However, the presence of light and oxygen causes astaxanthin degradation which affects low absorption rates in the human digestive system. Many encapsulation methods have been applied to enhance astaxanthin physical stability and bioavailability for medical and dietary uses. This review describes and compares various encapsulation methods used to astaxanthin. There are many typical methods for encapsulation that include nanoliposome, drying method, emulsification, coacervation and extrusion coating. In addition, encapsulation methods led to use for in vivo and in vitro studies were also discussed.

References

Aflalo, C., Meshulam, Y., Zarka, A. and Boussiba, S. 2007. On the relative efficiency of two- vs. one-stage production of astaxanthin by the green alga Haematococcus pluvialis. Biotechnology and Bioengineering. 98(1): 300-305.

Ambati, R. R., Phang, S.M., Ravi, S. and Aswathanarayana, R. G. 2014. Astaxanthin: sources, extraction, stability, biological activities and its commercial applications-A review. Marine Drugs. 12: 128-152.

Anarjan, N., Mirhosseini, H., Baharin, B.S. and Tan, C.P. 2011. Effect of processing conditions on physicochemical properties of sodium caseinat-stabilized astaxanthin nanodispersions. LWT-Food Science and Technology. 44(7): 1658-1665.

Anarjan, N., Nehdi, I.A. and Tan, C.P. 2013. Influence of astaxanthin, emulsifier and organic phase concentration on physicochemical properties of astaxanthin nanodispersions. Chemistry Central Journal. 7(1): 127.

Anderson, J. S. and Sunderland, R. 2002. Effect of extruder moisture and dryer processing temperature on vitamin C and E and astaxanthin stability. Aquaculture. 207(1-2): 137-149.

Armenta, R. E. and Guerrero-Legarreta, I. 2009. Stability studies on astaxanthin extracted from fermented shrimp byproducts. Journal of Agricultural and Food Chemistry. 57(14): 6095-6100.

Ansel, H. C., Popovich, N. G. and Allen, L. V. 1995. Pharmaceutical dosage forms and drug delivery system. 8th ed., New Delhi : B.I. Waverly Pvt. Ltd.

Banerjee, K., Ghosh, R., Homechaudhuri, S. and Mitra, A. 2009. Biochemical composition of marine macroalgae from gangetic delta at the apex of Bay of Bengal. African Journal of Basic and Applied Sciences. 1(5-6): 96-104.

Bustos-Garza, C., Yáñez-Fernández, J. and Barragán-Huerta, B.E. 2013. Thermal and pH stability of spray-dried encapsulated astaxanthin oleoresin from Haematococcus pluvialis using several encapsulation wall materials. Food Research International. 54: 641-649.

Chew, S.C. and Nyam, K.L. 2016. Microencapsulation of kenaf seed oil by coextrusion technology. Journal of Food Engineering. 175: 43-50.

Desai, K. G. and Park, H. J. 2005. Preparation of cross-linked chitosan microspheres by spray drying: Effect of cross-linking agent on the properties of spray dried microspheres. Journal of Microencapsulation. 22(4): 377-395.

Dima, S., Dima, C. and Iordachescu, G. 2015. Encapsulation of functional lipophilic food and drug biocomponents. Food Engineering Reviews. 7(4): 417-438.

Dong, S., Huang, Y., Zhang, R., Wang, S. and Liu, Y. 2014. Four different methods comparison for extraction of astaxanthin from green alga Haematococcus pluvialis. The Scientific World Journal. pp. 1-7.

Dordevic, V., Balanc, B., Belscak-Cvitanovic, A., Levic, S., Trifkovic, K., Kalusevic, A. And Nedovic, V. 2014. Trends in encapsulation technologies for delivery of food bioactive compounds. Food Engineering Reviews. 7(4): 452-490.

Durbeej, B. and Eriksson, L. A. 2006. Protein-bound chromophores astaxanthin and phytochromobilin: Excited state quantum chemical studies. Physical Chemistry Chemical Physics. 8(35): 4053-4071.

EFSA (European Food Safety Authority). 2005. Opinion of the scientific panel on additives and products or substances used in animal feed on the request from the European commission on the safety of use of colouring agents in animal human nutrition. EFSA Journal. 291: 1-40.

EFSA (European Food Safety Authority). 2007. Safety and efficacy of panaferd-AX(red carotenoid rich bacterium Paracoccus carotinifaciens as feed additive for salmon and trout. EFSA Journal. 546: 1-30.

Fang, Z. and Bhandari, B. 2010. Encapsulation of polyphenols-a review. Trends in Food Science and Technology. 21(10): 510-523.

Gomez-Estaca, J., Comunian, T. A., Montero, P., Ferro-Furtado R. and Favaro-Trindade C. S. 2016. Encapsulation of an astaxanthin-containing lipid extract from shrimp waste by complex coacervation using a novel gelatin-cashew gum complex. Food Hydrocolloids. 61: 155-162.

Gong, K.J. Shi, A.M., Liu, H.Z., Liu, L., Hu, H., Yang, Y., Adhikari, B. and Wang, Q. 2016. Preparation of nanoliposome loaded with peanut peptide fraction: Stability and bioavailability. Food and Function. 7(4): 2034-2042.

Higuera-Ciapara, I., Félix-Valenzuela, L. and Goycoolea, F.M. 2006. Astaxanthin: A review of its chemistry and applications. Critical Reviews in Food Science and Nutrition. 46(2): 185-196.

Holanda, H.D.D. and Netto, F.M. 2006. Recovery of components from shrimp (Xiphopena euskroyeri) processing waste by enzymatic hydrolysis. Journal of Food Science. 71: 298-303.

Jyothi, N. V., Prasanna, P. M., Sakarkar, S. N., Prabha, K. S., Ramaiah, P. S. and Srawan, G. 2010. Microencapsulation techniques, factors influencing encapsulation efficiency. Journal of Microencapsulation. 27(3): 187-197.

Kamath, B.S., Srikanta, B.M., Dharmesh, S.M., Sarada, R. and Ravishankar, G.A. 2008. Ulcer preventive and antioxidative properties of astaxanthin from Haematococcus pluvialis. European Journal of Pharmacology. 590(1-3): 387-395.

Kang, C.D. and Sim, S.J. 2008. Direct extraction of astaxanthin from Haematococcus culture using vegetable oils. Biotechnology Letters. 30: 441-444.

Khalid, N., Shu, G., Kobayashi, I., Nakajima, M. and Barrow, C.J. 2017. Formulation and characterization of monodisperse O/W emulsions encapsulating astaxanthin extracts using microchannel emulsification: Insights of formulation and stability evaluation. Colloids and Surfaces B: Biointerfaces. 157: 355-365.

Kim, J.H., Kang, S.W., Kim, S.W. and Chang, H.I. 2005. High-level production of astaxanthin by Xanthophyllomyces dendrorhous mutant JH1 using statistical experimental designs. Bioscience, Biotechnology and Biochemistry. 69(9): 1743-1748.

Lu, Q., Li, D.C. and Jiang, J.G. 2011. Preparation of a tea polyphenol nanoliposome system and its physicochemical properties. Journal of Agricultural and Food Chemistry. 59(24): 13004-13011.

Manca, M. L., Zaru, M., Manconi, M., Lai, F., Valenti, D., Sinico, C. and Fadda, A. M. 2013. Glycerosomes: A new tool for effective dermal and transdermal drug delivery. International Journal of Pharmaceutics. 455(1-2): 66-74.

Marín, D., Alemán, A., Sánchez-Faure, A., Montero, P. and Gómez-Guillén, M.C. 2018. Freeze-dried phosphatidylcholine liposomes encapsulating various antioxidant extracts from natural waste as functional ingredients in surimi gels. Food Chemistry. 245: 525-535.

Martínez-Delgado, A.A., Khandual, S. and Villanueva-Rodríguez, S.J. 2017. Chemical stability of astaxanthin integrated into a food matrix: effects of food processing and methods for preservation. Food Chemistry. 225: 23-30.

McClements, D.J. 2012. Nanoemulsions versus microemulsions: terminology, differences, and similarities. Soft Matter. 8: 1719-1729.

Miao, F., Lu, D., Li, Y. and Zeng, M. 2006. Characterization of astaxanthin esters in Haematococcus pluvialis by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry. Analytical Biochemistry. 352(2): 176-181.

Mozafari, M. R. 2005. Liposomes: An overview of manufacturing techniques. Cellular and Molecular Biology Letters. 10(4): 711-719.

Niizawa, I., Espinaco, Y.B., Zorrilla, E.S. and Sihufe, A.G. 2019. Natural astaxanthin encapsulation: Use of response surface methodology for the design of alginate beads. International Journal of Biological Macromolecules. 121(7): 601-608.

Olaizola, M. 2000. Commercial production of astaxanthin from Haematococcus pluvialis using 25,000-liter outdoor photobioreactors. Journal of Applied Phycology. 12: 499-506.

Onder, E., Sarier, N. and Cimen, E. 2008. Encapsulation of phase change materials by complex coacervation to improve thermal performances of woven fabric. Thermochimica Acta. 467(1-2): 63-72.

Orosa, M., Torres, E., Fidalgo, P. and Abalde, J. 2000. Production and analysis of secondary carotenoids in green algae. Journal of Applied Phycology. 12(3): 553-556.

Pan, L., Wang, H. and Gu, K. 2018. Nanoliposomes as vehicles for astaxanthin: characterization, in vitro release evaluation and structure. Molecules. 23(11): 2822-2834.

Pimentel-Moral, S., Verardo, V., Robert, P., Segura-Carretero, A. and Martinez-Ferez, A. 2016. Nanoencapsulation strategies applied to maximize target delivery of intactpolyphenols. Encapsulations. pp. 559-595.

Prusse, U., Bilancetti, L., Bucko, M., Bugarski, B., Bukowski, J., Gemeiner, P., Lewinska, D., Manojlovic, V., Massart, B., Nastruzzi, C., Nedovic, V., Poncelet, D., Siebenhaar, S., Tobler, L., Tosi, A., Vikartovska, A. and Vorlop, K.D. 2008. Comparison of different technologies for alginate beads production. Chemical Papers. 62(4): 364-374.

Ranga, R.A., Raghunath, R.R.L., Baskaran, V., Sarada, R. and Ravishankar, G.A. 2010. Characterization of microalgal carotenoids by mass spectrometry and their bioavailability and antioxidant properties elucidated in rat model. Journal of Agricultural and Food Chemistry. 58(15): 8553–8559.

Saini, R. K. and Keum, Y.S. 2017. Progress in microbial carotenoids production. Indian Journal of Microbiology. 57(1): 129-130.

Shen, Q. and Quek, S.Y. 2014. Microencapsulation of astaxanthin with blends of milk protein and fiber by spray drying. Journal of Food Engineering. 123: 165-171.

Singh, M.N., Hemant, K.S.Y., Ram, M. and Shivakumar, H.G. 2011. Microencapsulation: a promising technique for controlled drug delivery. Research in Pharmaceutical Sciences. 5(2): 65-77.

Singh, S. and Rather, A.H. 2018. Extraction of astaxanthin from the encysted cells of Haematococcus pluvialis with different solvents. Research Journal of Life Sciences, Bioinformatics, Pharmaceutical and Chemical Sciences. 4(1): 115-124.

Stark, B., Pabst, G. and Prassl, R. 2010. Long-term stability of sterically stabilized liposomes by freezing and freeze-drying: Effects of cryoprotectants on structure. European Journal of Pharmaceutical Sciences. 41(3-4): 546-555.

Tachaprutinun, A., Udomsup, T., Luadthong, C. and Wanichwecharungruang, S. 2009. Preventing the thermal degradation of astaxanthin through nanoencapsulation. International Journal of Pharmaceutics. 374(1-2): 119-124.

Taksima, T., Limpawattana, M. and Klaypradit, W. 2015. Astaxanthin encapsulated in beads using ultrasonic atomizer andapplication in yogurt as evaluated by consumer sensory profile. LWT-Food Science and Technology. 62(1): 431-437.

Tan, C., Feng, B., Zhang, X., Xia, W. and Xia, S. 2016. Biopolymer-coated liposomes by electrostatic adsorption of chitosan (chitosomes) as novel delivery systems for carotenoids. Food Hydrocolloids. 52: 774-784.

Torzillo, G., Goksan, T., Faraloni, C., Kopecky, J. and Masojídek, J. 2003. Interplay between photochemical activities and pigment composition in an outdoor culture of Haematococcus pluvialis during the shift from the green to red stage. Journal of Applied Phycology. 15: 127-136.

Tropea, A., Gervasi, T., Melito, M.R., Curto, A.L. and Curto, R.L. 2013. Does the light influence astaxanthin production in Xanthophyllomyces dendrorhous?. Natural Product Research. 27(7): 647-653.

Vakarelova, M., Zanoni, F., Lardo, P., Rossin, G., Mainente, F., Chignola, R., Menin, A., Rizzi, C. and Zoccatelli, G. 2017. Production of stable food-grade microencapsulated astaxanthin by vibrating nozzle technology. Food Chemistry. 221: 289-295.

Vladisavljevic, G.T., Kobayashi, I. and Nakajima, M. 2012. Production of uniform droplets using membrane, microchannel and microfluidic emulsification devices. Microfluid Nanofluid. 13(1): 151-178.

Wang, J., Han, D., Sommerfeld, M.R., Lu, C. and Hu, Q. 2013. Effect of initial biomass density on growth and astaxanthin production of Haematococcus pluvialis in an outdoor photobioreactor. Journal of Applied Phycology. 25(1): 253-260.

Wilson, N. and Shan, N.P. 2007. Microencapsulation of vitamins. ASEAN Food Journal. 14(1): 1-5.

Yamashita, E. 2013. Astaxanthin as a medical food. Functional Foods in Health and Disease. 3(7): 254-258.

Yokoyama, A., Adachi, K. and Shizuri, Y. 1995. New carotenoid glucosides, astaxanthin glucoside and adonixanthin glucoside, isolated from the astaxanthin-producing marine bacterium, agrobacterium aurantiacum. Journal of Natural Products. 58(12): 1929-1933.

Yuan, J.P., Peng, J., Yin, K. and Wang, J.H. 2011. Potential health-promoting effects of astaxanthin: A high-value carotenoid mostly from microalgae. Molecular Nutrition and Food Research. 55(1): 150-165.

Zhang, D.H. and Lee, Y.K. 1997. Enhanced accumulation of secondary carotenoids in a mutant of the green alga, Chlorococcum sp. Journal of Applied Phycology. 9: 459-463.

Zhang, D.H., Ng, M.L. and Phang, S.M. 1997. Composition and accumulation of secondary carotenoids in Chlorococcum sp. Journal of Applied Phycology. 9(2): 147-155.

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Published

2021-08-25

How to Cite

Kraboun, Dr.Kitisart. 2021. “Antioxidant Properties and Encapsulation Methods of Astaxanthin: A Review”. Food and Applied Bioscience Journal 9 (2):22-39. https://li01.tci-thaijo.org/index.php/fabjournal/article/view/243185.

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Food Biotechnology, Microbiology and Food Safety & Quality