The study of the proportions of couples who obtained their at-risk/non-risk results and prenatal diagnosis outcomes of severe thalassemia within various gestational ages
Keywords:
At-risk couple, Prenatal diagnosis, ThalassemiaAbstract
Each step of the prenatal screening for thalassemia is subject to time constraints. This study aimed to demonstrate the outcome of a thalassemia prenatal control program by determining the proportions of couples who obtained their at-risk/non-risk results and their prenatal diagnosis (PND) outcomes within various gestational ages (GA). The study was conducted using prenatal control record for thalassemia disease in the lower northern region between January 2014 and December 2016. Pregnancies without record of GA were excluded. Proportions of couples who received their at-risk/non-risk and PND results within the GA of 16 through 24 weeks were analyzed. Among 4,633 couples determined, the median GA was 12.4 weeks when blood samples were submitted for thalassemia screening, and 13.9 weeks when at-risk/non-risk results were communicated. Proportions of couples who obtained their at-risk/non-risk results within the GA of 16, 18, and 20 weeks were 64.9% (3,005 cases), 73.8% (3,421 cases), and 81.2% (3,761 cases), respectively. Among 359 PNDs evaluated, the median GA was 18.0 weeks when the PND was performed and 20.1 weeks when the PND results were disclosed. Proportions of couples who obtained their PND results within the GA of 16, 18, 20, 22, and 24 weeks were 0.6% (2 cases), 6.7% (24 cases), 47.4% (170 cases), 81.9% (294 cases), and 92.5% (332 cases), respectively. This outcome could reflect our real-world efficacy of prenatal control program for thalassemia in the lower northern region which needs improvement.
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