การยับยั้งการเจริญของจุลินทรีย์ก่อโรคและการเป็นพิษต่อเซลล์มะเร็ง ด้วยสารสกัดจากต้นโทงเทง
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การศึกษาสารสกัดจากต้นโทงเทง (Physalis angulata) ด้วยเครื่องอัลตราโซนิกความถี่ 45 กิโลเฮิรตซ์ ที่อุณหภูมิ 40 องศาเซลเซียส นาน 30 นาที พบว่า ให้ผลการต้าน DPPH การต้านแบคทีเรียก่อโรค 4 ชนิด คือ Mycobacterium tuberculosis, Klebsiella pneumoniae, Magnaporthe grisea และ Alternaria brassicicola รวมถึงการทดสอบการต้านเซลล์มะเร็งในหลอดทดลอง 3 ชนิด คือ เซลล์มะเร็งปอด (NCI-H187) เซลล์มะเร็งตับ (HepG2) เซลล์มะเร็งช่องปาก (KB) และเซลล์มะเร็งลำไส้ใหญ่ (Caco2) จากการทดสอบพบว่า ค่า IC50 การต้านอนุมูลอิสระ DPPH สารสกัดเมทานอลจากราก ลำต้น ใบและผล สารสกัดอะซิโตนจากราก ใบและผล แตกต่างอย่างไม่มีนัยสำคัญกับ ค่า IC50 ของกรดแอสคอร์บิก (p³0.05) มีค่า 97.52±22.29, 321.11±160.79, 109.25±7.76, 98.00±3.93, 218.86±55.25, 132.22±7.63, 109.09±7.45 และ 26.00±0.36 µg/ml ตามลำดับ สารสกัดเฮกเซนจากราก มีค่า IC50 สูงสุด แตกต่างอย่างมีนัยสำคัญทางสถิติกับสารสกัดอะซิโตนและเมทานอล มีค่า IC50 เท่ากับ 546.89±216.91 µg/ml พบว่า สารสกัดอะซิโตนจากผลยับยั้งการเจริญของเชื้อ M. tuberculosis ได้ดีกว่าเชื้อ K. pneumoniae เชื้อ M. grisea และเชื้อ A. brassicicola อย่างมีนัยสำคัญ และนอกจากนี้สารสกัดดังกล่าวยังมีความเป็นพิษต่อเซลล์มะเร็งปอดซึ่งมีความแตกต่างจากเซลล์มะเร็งตับ เซลล์มะเร็งช่องปาก และเซลล์มะเร็งลำไส้ใหญ่อย่างมีนัยสำคัญ (p<0.05) อีกด้วย แนวทางการใช้ประโยชน์จากการศึกษานี้ เพื่อส่งเสริมการใช้สมุนไพรเพื่อลดไขมันสะสมเกินความจำเป็น
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ต้นฉบับที่ได้รับการตีพิมพ์ถือเป็นสิทธิของเจ้าของต้นฉบับและของวารสารวิชาการ มทร.สุวรรณภูมิ เนื้อหาบทความในวารสารเป็นแนวคิดของผู้แต่ง มิใช่เป็นความคิดเห็นของคณะกรรมการการจัดทำวารสาร และมิใช่ความรับผิดชอบของมหาวิทยาลัยเทคโนโลยีราชมงคลสุวรรณภูมิ
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