Anticancer activity of Pogonatherum paniceum Extract against HCT116 Human Colorectal Cancer Cells
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Abstract
Pogonatherum paniceum is a type of grass known to have detoxification activity. However, very few studies of its anticancer activity have been evident. Therefore, this research aimed to examine the anticancer activity of P. paniceum extract against HCT116 human colorectal cancer cells. This research investigated the effect of P. paniceum extract on viability of HCT116 cells by the MTT assay, proliferation of HCT116 cells by the clonogenic assay, migration of HCT116 cells by the wound healing assay and cell cycle of HCT116 cells by flow cytometry. The results demonstrated that the P. paniceum extract caused the reduction in viability of HCT116 cells in a dose dependent manner. The percentages of viability of HCT116 cells were 81.92, 67.03 and 63.27 when HCT116 cells were incubated with 1, 1.25 and 1.5 mg/mL of the P. paniceum extract for 48 h, respectively. It was also found that the P. paniceum extract was able to suppress proliferation and diminish migration of HCT116 cells. It was also able to induce cell cycle arrest of HCT116 cells at G0/G1 phase. This research suggested that the P. paniceum extract exhibited anticancer activity against HCT116 human colorectal cancer cells and might be an alternative for cancer treatment.
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บทความที่ได้รับการตีพิมพ์เป็นลิขสิทธิ์ของ วารสารวิทยาศาสตร์และเทคโนโลยี มหาวิทยาลัยอุบลราชธานี
ข้อความที่ปรากฏในบทความแต่ละเรื่องในวารสารวิชาการเล่มนี้เป็นความคิดเห็นส่วนตัวของผู้เขียนแต่ละท่านไม่เกี่ยวข้องกับมหาวิทยาลัยอุบลราชธานี และคณาจารย์ท่านอื่นๆในมหาวิทยาลัยฯ แต่อย่างใด ความรับผิดชอบองค์ประกอบทั้งหมดของบทความแต่ละเรื่องเป็นของผู้เขียนแต่ละท่าน หากมีความผิดพลาดใดๆ ผู้เขียนแต่ละท่านจะรับผิดชอบบทความของตนเองแต่ผู้เดียว
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