Formulation and stability of Prasaplai microemulsions

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Published: Apr 30, 2021
DOI: https://doi.org/10.14456/sehs.2021.17
Keywords:
Prasaplai microemulsions isopropyl myristate tea-tree oil stability

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Pattravadee Buranatrakul
Department of Pharmaceutical Technology, Faculty of Pharmacy, Srinakharinwirot University, Nakorn Nayok, Thailand. Corresponding author's e-mail:pattravadee@g.swu.ac.th
Chayanid Sornchaithawatwong
Department of Chemistry, Faculty of Pharmacy, Srinakharinwirot University, Nakorn Nayok, Thailand
Thanu Thongnopkoon
Department of Pharmaceutical Technology, Faculty of Pharmacy, Srinakharinwirot University, Nakorn Nayok, Thailand
Kewarin Phumchalao
Department of Pharmaceutical Technology, Faculty of Pharmacy, Srinakharinwirot University, Nakorn Nayok, Thailand
Piyaporn Naksrichum
Department of Pharmaceutical Technology, Faculty of Pharmacy, Srinakharinwirot University, Nakorn Nayok, Thailand
Watoo Phrompittayarat
Department of Applied Thai Traditional Medicine, Faculty of Public Health, Naresuan University, Phitsanulok, Thailand

Abstract

Prasaplai is a Thai herbal remedy used in obstetrics and gynecology. In this study, Prasaplai microemulsions (MEs) were developed for topical use, using two types of oil: isopropyl myristate (IPM) and tea tree oil, with polysorbate 80 and butanol as the surfactant and co-surfactant, respectively. The stability of Prasaplai MEs under accelerated conditions was studied. Prasaplai MEs from both oil types had a clear yellow color, with a diameter between 236 and 257 nm. The pH values of all ME were between 5.14 and 5.45, and the viscosities were between 19 and 26 centipoises, with Newtonian flow behavior. After storage under accelerated conditions, the tea tree oil-based MEs showed phase separation, whereas the IPM-based MEs were homogeneous. The size of the tea tree oil-based MEs increased, while pH decreased after storage. The decrease in pH indicated the presence of degradation products in the formulations. The IPM-based Prasaplai MEs reduced in size, and the pH value increased. The amount of remaining curcumin was 73.80% in the tea tree oil-based MEs and 92.20 % in the IPM-based MEs. In conclusion, oil types and ingredients in Prasaplai affects the stability of the MEs. IPM-based Prasaplai MEs might be better for use as topically applied remedies.

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How to Cite
Buranatrakul, P., Sornchaithawatwong, C., Thongnopkoon, T., Phumchalao, K., Naksrichum, P., & Phrompittayarat, W. (2021). Formulation and stability of Prasaplai microemulsions. Science, Engineering and Health Studies, 15, 21050004. https://doi.org/10.14456/sehs.2021.17
Issue
Volume 15, 2021
Section
Health sciences

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