Electrospun nanofibers from natural polymers and their application

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Published: Dec 16, 2021
DOI: https://doi.org/10.14456/sehs.2021.29
Keywords:
electrospinning electrospun nanofiber wound dressing drug carrier shellac

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Nawinda Chinatangkul
Faculty of Pharmacy, Siam University, Bangkok, Thailand
Chutima Limmatvapirat
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand
Sontaya Limmatvapirat
Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand. Corresponding author's e-mail: limmatvapirat_s@su.ac.th

Abstract

Due to their small structure and large number of micropores, nanofibers can be employed effectively in a variety of applications, including drug delivery, wound dressing, tissue engineering, filtration, and in cosmetic products. Several fabrication techniques have recently been developed to produce nanofibers. Electrospinning has been widely used owing to its high-degree of flexibility in fabrication and its suitability for use in industrial-scale production. Both synthetic and natural polymers have been employed in the process of electrospinning nanofibers. Natural polymers appear to be particularly attractive materials for use in this process because their structures are similar to those found in extracellular matrices prevalent in the human body, resulting in a compatible interaction with this biological environment. This review summarizes the current development of nanofibers produced from natural polymers and their application in various fields. Fabrication limitations and future application are also considered.

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How to Cite
Chinatangkul, N., Limmatvapirat, C., & Limmatvapirat, S. (2021). Electrospun nanofibers from natural polymers and their application. Science, Engineering and Health Studies, 15, 21010005. https://doi.org/10.14456/sehs.2021.29
Issue
Volume 15, 2021
Section
Editorials and Reviews
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This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

References

Ambekar, R. S., and Kandasubramanian, B. (2019). Advancements in nanofibers for wound dressing: A review. European Polymer Journal, 117, 304-336.

Barot, M., Gokulgandhi, M., Ray, A., and Mitra, A. (2014). Nanofiber. In Advanced Drug Delivery (Mitra, A., Lee, C., and Cheng, K., eds.), 1st, pp. 219-230. Hoboken, New Jersey: John Wiley & Sons, Inc.

Bazilevsky, A. V., Yarin, A. L., and Megaridis, C. M. (2007). Co-electrospinning of core-shell fibers using a single-nozzle technique. Langmuir, 23(5), 2311-2314.

Braghirolli, D. I., Steffens, D., and Pranke, P. (2014). Electrospinning for regenerative medicine: a review of the main topics. Drug Discovery Today, 19(6), 743-753.

Cai, M., He, H., Zhang, X., Yan, X., Li, J., Chen, F., Yuan, D., and Ning, X. (2019). Efficient synthesis of PVDF/PI side-by-side bicomponent nanofiber membrane with enhanced mechanical strength and good thermal stability. Nanomaterials, 9(1), 39.

Chen, Q., Liu, Y., Deng, H., Lyu, T., Tan, J., Yang, W., Li, H., and Ramakrishna, S. (2020). Melt differential electrospinning of polyphenylene sulfide nanofibers for flue gas filtration. Polymer Engineering and Science, 60(11), 2887-2894.

Cheng, T., Xu, L., and Wang, M. (2019). Effect of surface active agent on bubble-electrospun polyacrylonitrile nanofibers. Thermal Science, 23(4), 2481-2487.

Chinatangkul, N., Limmatvapirat, C., Nunthanid, J., Luangtana-Anan, M., Sriamornsak, P., and Limmatvapirat, S. (2018). Design and characterization of monolaurin loaded electrospun shellac nanofibers with antimicrobial activity. Asian Journal of Pharmaceutical Sciences, 13(5), 459-471.

Chinatangkul, N., Pengon, S., Limmatvapirat, C., and Limmatvapirat, S. (2017). Design of experiment approach for fabrication process of electrospun shellac nanofibers using factorial designs. Key Engineering Materials, 757, 120-124.

Dai, T., Tanaka, M., Huang, Y. Y., and Hamblin, M. R. (2011). Chitosan preparations for wounds and burns: antimicrobial and wound-healing effects. Expert Review of Anti-Infective Therapy, 9(7), 857-879.

Denis, P., Dulnik, J., and Sajkiewicz, P. (2015). Electrospinning and structure of bicomponent polycaprolactone/gelatin nanofibers obtained using alternative solvent system. Journal of International Polymeric Materials and Polymeric Biomaterials, 64(7), 354-364.

Dou, H., and Liu, H. (2013). Fabrication of micro yarn composed of nanofibers by blown bubble spinning. Advanced Materials Research, 843, 74-77.

Erickson, A. E., Edmondson, D., Chang, F. C., Wood, D., Gong, A., Levengood, S. L., and Zhang, M. (2015). High-throughput and high-yield fabrication of uniaxially-aligned chitosan-based nanofibers by centrifugal electrospinning. Carbohydrate Polymers, 134, 467-474.

Fang, J., Niu, H., Lin, T., and Wang, X. (2008). Applications of electrospun nanofibers. Chinese Science Bulletin, 53(15), 2265-2286.

Hadipour-Goudarzi, E., Montazer, M., Latifi, M., and Aghaji, A. A. G. (2014). Electrospinning of chitosan/sericin/PVA nanofibers incorporated with in situ synthesis of nano silver. Carbohydrate Polymers, 113, 231-239.

Han, D., and Steckl, A. J. (2013). Triaxial electrospun nanofiber membranes for controlled dual release of functional molecules. ACS Applied Materials and Interfaces, 5(16), 8241-8245.

Han, D., and Steckl, A. J. (2019). Coaxial electrospinning formation of complex polymer fibers and their applications. ChemPlusChem, 84(10), 1453-1497.

Hao, D. O. U., Hong-Yan, L. I. U., Ping, W., and Ji-Huan, H. E. (2014). Effect of solution concentrations on the morphology of nylon6/66 nanofibrous yarns by blown bubble-spinning. Matéria, 19(4), 358-362.

He, J. H. (2012). The smaller, the better: From the spider-spinning to bubble-electrospinning. Acta Physica Polonica A, 121, 254-256.

He, J., and Zhou, Y. (2019). Multineedle electrospinning. In Electrospinning: Nanofabrication and Applications (Ding, B., Wang, X., and Yu, J., eds.), pp. 201-218. Norwich, New York: William Andrew Publishing.

Homayoni, H., Ravandi, S. A. H., and Valizadeh, M. (2009). Electrospinning of chitosan nanofibers: processing optimization. Carbohydrate Polymers, 77(3), 65-661.

Huang, Z. M., Zhang, Y. Z., Kotaki, M., and Ramakrishna, S. (2003). A review on polymer nanofibers by electrospinning and their applications in nanocomposites. Composites Science and Technology, 63(15), 2223-2253.

Jalaja, K., and James, N. R. (2015). Electrospun gelatin nanofibers: A facile cross-linking approach using oxidized sucrose. International Journal of Biological Macromolecules, 73, 270-278.

Jin, G., Lee, S., Kim, S. H., Kim, M., and Jang, J. H. (2014). Bicomponent electrospinning to fabricate three-dimensional hydrogel-hybrid nanofibrous scaffolds with spatial fiber tortuosity. Biomedical Microdevices, 16(6), 793-804.

Kajdič, S., Planinšek, O., Gašperlin, M., and Kocbek, P. (2019). Electrospun nanofibers for customized drug-delivery systems. Journal of Drug Delivery Science and Technology, 51, 672-681.

Kancheva, M., Toncheva, A., Manolova, N., and Rashkov, I. (2014). Advanced centrifugal electrospinning setup. Materials Letters, 136, 150-152.

Kundu, J., Pati, F., Hun Jeong, Y., and Cho, D.-W. (2013). Biomaterials for biofabrication of 3D tissue scaffolds. In Biofabrication (Forgacs, G., and Sun, W., eds.), pp. 23-46. Norwich, New York: William Andrew Publishing.

Lee, B. S., Yang, H. S., and Yu, W. R. (2014). Fabrication of double-tubular carbon nanofibers using quadruple coaxial electrospinning. Nanotechnology, 25(46), 465602.

Levengood, S. L., Erickson, A. E., Chang, F., and Zhang, M. (2017). Chitosan-poly(caprolactone) nanofibers for skin repair. Journal of Materials Chemistry B, 5(9), 1822-1833.

Li, H., Wang, M., Williams, G. R., Wu, J., Sun, X., Lv, Y., and Zhu, L. M. (2016). Electrospun gelatin nanofibers loaded with vitamins A and E as antibacterial wound dressing materials. RSC Advances, 6(55), 50267-50277.

Liao, N., Unnithan, A. R., Joshi, M. K., Tiwari, A. P., Hong, S. T., Park, C. H., and Kim, C. S. (2015). Electrospun bioactive poly (ɛ-caprolactone)-cellulose acetate–dextran antibacterial composite mats for wound dressing applications. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 469, 194-201.

Limmatvapirat, S., Limmatvapirat, C., Luangtana-anan, M., Nunthanid, J., Oguchi, T., Tozuka, Y., Yamamoto, K., and Puttipipatkhachorn, S. (2004). Modification of physicochemical and mechanical properties of shellac by partial hydrolysis. International Journal of Pharmaceutics, 278(1), 41-49.

Lu, B., Wang, Y., Liu, Y., Duan, H., Zhou, J., Zhang, Z., Wang, Y., Li, X., Wang, W., Lan, W., and Xie, E. (2010). Superhigh-throughput needleless electrospinning using a rotary cone as spinneret. Small, 6(15), 1612-1616.

Luangtana-Anan, M., and Limmatvapirat, S. (2019). Shellac-based coating polymer for agricultural applications. In Polymers for Agri-Food Applications (Gutiérrez, T., ed.), pp. 487-524. Copenhagen, Denmark: Springer Cham.

Ma, K., Qiu, Y., Fu, Y., and Ni, Q. Q. (2018). Electrospun sandwich configuration nanofibers as transparent membranes for skin care drug delivery systems. Journal of Materials Science, 53(15), 10617-10626.

Mingjun, C., Youchen, Z., Haoyi, L., Xiangnan, L., Yumei, D., Bubakir, M. M., and Weimin, Y. (2019). An example of industrialization of melt electrospinning: polymer melt differential electrospinning. Advanced Industrial and Engineering Polymer Research, 2(3), 110-115.

Muniz, N. O., Vechietti, F. A., Anesi, G. R., Guinea, G. V, and dos Santos, L. A. L. (2020). Blend-based fibers produced via centrifugal spinning and electrospinning processes: physical and rheological properties. Journal of Materials Research, 35(21), 2905-2916.

Muthuraman, A., and Kaur, J. (2017). Antimicrobial nanostructures for neurodegenerative infections: Present and future perspectives. In Nanostructures for Antimicrobial Therapy (Ficai, A., and Grumezescu, A. M., eds.), pp. 139-167. Amsterdam, Netherlands: Elsevier.

Nuryantini, A. Y., Munir, M. M., Ekaputra, M. P., Suciati, T., and Khairurrijal, K. (2014). Electrospinning of poly (vinyl alcohol)/chitosan via multi-nozzle spinneret and drum collector. Advanced Materials Research, 896, 41-44.

Okamoto, M. Y., and Ibanez, P. S. (1986). Final report on the safety assessment of shellac. Journal of the American College of Toxicology, 5(5), 309-327.

Pedram, R. Z., Mokhtari, J., and Abbasi, M. (2018). Fabrication and characterization of PCL/zein/gum arabic electrospun nanocomposite scaffold for skin tissue engineering. Materials Science and Engineering, 93, 356-366.

Pezeshki-Modaress, M., Zandi, M., and Rajabi, S. (2018). Tailoring the gelatin/chitosan electrospun scaffold for application in skin tissue engineering: an in vitro study. Progress in Biomaterials, 7(3), 207-218.

Potrč, T., Baumgartner, S., Roškar, R., Planinšek, O., Lavrič, Z., Kristl, J., and Kocbek, P. (2015). Electrospun polycaprolactone nanofibers as a potential oromucosal delivery system for poorly water-soluble drugs. European Journal of Pharmaceutical Sciences, 75, 101-113.

Ramakrishna, S., Fujihara, K., Teo, W. E., Lim, T. C., and Ma, Z. (2005). An Introduction to Electrospinning and Nanofibers, Singapore: World Scientific, pp. 7-116.

Salas, C., Thompson, Z., and Bhattarai, N. (2017). 15 - Electrospun chitosan fibers. In Electrospun Nanofibers (Afshari, M., ed.), pp. 371-398. Cambridge, Massachusetts: Woodhead Publishing.

Senel, S., and McClure, S. J. (2004). Potential applications of chitosan in veterinary medicine. Advanced Drug Delivery Reviews, 56(10), 1467-1480.

Skaria, S. D., and Smaldone, G. C. (2014). Respiratory source control using surgical masks with nanofiber media. The Annals of Occupational Hygiene, 58(6), 771-781.

Sun, F., Yao, C., Song, T., and Li, X. (2011). Fabrication of poly(vinylidenefluoride‐co‐hexafluoropropylene) nanofiber yarns by conjugate electrospinning. The Journal of The Textile Institute, 102(7), 633-638.

Sundarrajan, S., Tan, K. L., Lim, S. H., and Ramakrishna, S. (2014). Electrospun nanofibers for air filtration applications. Procedia Engineering, 75, 159-163.

Tang, S., Zeng, Y., and Wang, X. (2010). Splashing needleless electrospinning of nanofibers. Polymer Engineering and Science, 50(11), 2252-2257.

Thoppey, N., Bochinski, J., Clarke, L., and Gorga, R. (2011). Edge electrospinning for high throughput production of quality nanofibers. Nanotechnology, 22(34), 345301.

Thoppey, N. M., Bochinski, J. R., Clarke, L. I., and Gorga, R. E. (2010). Unconfined fluid electrospun into high quality nanofibers from a plate edge. Polymer, 51(21), 4928-4936.

Unnithan, A. R., Barakat, N. A. M., Pichiah, P. B. T., Gnanasekaran, G., Nirmala, R., Cha, Y. S., Jung, C. H., El-Newehy, M., and Kim, H. Y. (2012). Wound-dressing materials with antibacterial activity from electrospun polyurethane-dextran nanofiber mats containing ciprofloxacin HCl. Carbohydrate Polymers, 90(4), 1786-1793.

Unnithan, A. R., Gnanasekaran, G., Sathishkumar, Y., Lee, Y. S., and Kim, C. S. (2014). Electrospun antibacterial polyurethane-cellulose acetate-zein composite mats for wound dressing. Carbohydrate Polymers, 102, 884-892.

Utracki, L. A. (2002). Introduction to polymer blends. In Polymer Blends Handbook (Utracki, L. A., ed.), pp. 1-122. Dordrecht, Netherlands: Kluwer Academic Publishers.

Vannuruswamy, G., Rathna, G. V. N., Gadgil, B. S. T., and Gadad, A. P. (2015). Blnds of shellac as nanofiber formulations for wound healing. Journal of Bioactive and Compatible Polymers, 30(5), 472-489.

Vasita, R., andKatti, D. S. (2006). Nanofibers and their applications in tissue engineering. International Journal of Nanomedicin, 1(1), 15-30.

Wang, X., Yu, D. G., Li, X. Y., Bligh, S. W. A., and Williams, G. R. (2015). Electrospun medicated shellac nanofibers for colon-targeted drug delivery. International Journal of Pharmaceutics, 490(1-2), 384-390.

Xinsong, L., Yao, C., Sun, F., Song, T., Li, Y., and Pu, Y. (2008). Conjugate electrospinning of continuous nanofiber yarn of poly(L‐lactide)/nanotricalcium phosphate nanocomposite. Journal of Applied Polymer Science, 107(6), 3756-3764.

Xu, Y., Li, X., Xiang, H. F., Zhang, Q. Q., Wang, X. X., Yu, M., Hao, L. Y., and Long, Y. Z. (2020). Large-scale preparation of polymer nanofibers for air filtration by a new multineedle electrospinning device. Journal of Nanomaterials, 2020, 4965438.

Yang, R., He, J., Xu, L., and Yu, J. (2009). Bubble-electrospinning for fabricating nanofibers. Polymer, 50(24), 5846-5850.

Yao, Q., Cosme, J. G. L., Xu, T., Miszuk, J. M., Picciani, P. H. S., Fong, H., and Sun, H. (2017). Three dimensional electrospun PCL/PLA blend nanofibrous scaffolds with significantly improved stem cells osteogenic differentiation and cranial bone formation. Biomaterials, 115, 115-127.

Yarin, A. L., and Zussman, E. (2004). Upward needleless electrospinning of multiple nanofibers. Polymer, 45(9), 2977-2980.

Yu, D. G., Li, X. Y., Wang, X., Yang, J. H., Bligh, S. W. A., and Williams, G. R. (2015). Nanofibers fabricated using triaxial electrospinning as zero order drug delivery systems. ACS Applied Materials and Interfaces, 7(33), 18891-18897.

Zahedi, P., Rezaeian, I., Ranaei-Siadat, S. O., Jafari, S. H., and Supaphol, P. (2009). A review on wound dressings with an emphasis on electrospun nanofibrous polymeric bandages. Polymers for Advanced Technologies, 21(2), 77-95.