Asymmetric synthesis of (1S,2S)-hydroxy cyclohexene-1,2,3-triazole derivatives
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Abstract
In this study, four (1S,2S)-hydroxycyclohexene-triazoles were synthezeid from 1,4-cyclohexadiene via epoxidation, epoxide ring-opening, and click reactions. The epoxidation of 1,4-cyclohexadiene yielded the monoepoxide cyclohexene. Subsequent epoxide ring-opening of epoxide catalyzed by the Salen
complex produced (1S,6S)-6-azidocyclohex-3-enol. These four (1S,2S)-hydroxycyclohexene-triazoles were synthesized via a final click reaction of (1S,6S)-6-azidocyclohex-3-enol with four different alkynes, i.e., propargyl amine, 2-propyn-1-ol, propargyl bromide, and 1-ethylanisole.
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