Synthesis of trans tert-butyl (5,6-dihydroxycyclohex-3-en-1-yl) carbamate: a potential precursor for (-)-muricatacin derivatives
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Abstract
This study examined the concise synthesis of dihydroxy trans-N-Boc cyclohexene, which could serve as a key starting material for the production of various biologically-active g-butyrolactones, particularly (-)-muricatacin. The synthesis began with meso-monoepoxide cyclohexene and encompassing the catalytic opening of the epoxide ring via the Salen complex that yielded trans-azido cyclohexene, azide reduction, N-Boc protection, and allylic hydroxylation.
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