Recent advances in 3D printing for floating drug delivery platforms

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Pornsak Sriamornsak
Kampanart Huanbutta
Tanikan Sangnim


Floating drug delivery is a gastro-retentive delivery system offering an advantage for poor-bioavailability drugs, which have low absorption in the upper gastrointestinal tract. This system can be administered effectively, increasing bioavailability and optimizing absorption. This technique can also prolong drug release, resulting in less frequent drug administration throughout the day. However, key restrictions of floating drug delivery are the ability to change drug dosage, drug release kinetics, buoyant force, and duration to suit each patient. With the constraints of the conventional manufacturing process, 3D printing has been developed to produce floating drug delivery devices with flexible dosage forms. This review summarizes studies that used different 3D printing techniques and materials to produce their own floating drug delivery systems and also discuss the limitation of this manufacturing technique.


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Babbar, A., Jain, V., Gupta, D., Prakash, C., Singh, S., and Sharma, A. (2020). 3D Bioprinting in pharmaceuticals, medicine, and tissue engineering applications. In Advanced Manufacturing and Processing Technology (Prakash, C., Singh, S., and Davim, J. P., eds.), 1st ed., pp. 147-161. Boca Raton, Florida: CRC Press.

Bansal, M., Sharma, V., Singh, G., and Harikumar, S. L. (2018). 3D printing for the future of pharmaceuticals dosages forms. International Journal of Applied Pharmaceutics, 10(3), 1-7.

Buanz, A. B. M., Saunders, M. H., Basit, A. W., and Gaisford, S. (2011). Preparation of personalized-dose salbutamol sulphate oral films with thermal ink-jet printing. Pharmaceutical Research, 28(10), 2386-2392.

Charoenying, T., Patrojanasophon, P., Ngawhirunpat, T., Rojanarata, T., Akkaramongkolporn, P., and Opanasopit, P. (2020a). Fabrication of floating capsule-in-3D-printed devices as gastro-retentive delivery systems of amoxicillin. Journal of Drug Delivery Science and Technology, 55, 101393.

Charoenying, T., Patrojanasophon, P., Ngawhirunpat, T., Rojanarata, T., Akkaramongkolporn, P., and Opanasopit, P. (2020b). Three-dimensional (3D)-printed devices composed of hydrophilic cap and hydrophobic body for improving buoyancy and gastric retention of domperidone tablets. European Journal of Pharmaceutical Sciences, 155, 105555.

Chavanpatil, M. D., Jain, P., Chaudhari, S., Shear, R., and Vavia, P. R. (2006). Novel sustained release, swellable and bioadhesive gastroretentive drug delivery system for ofloxacin. International Journal of Pharmaceutics, 316(1-2), 86-92.

Chen, P., Liu, J., Zhang, K., Huang, D., Huang, S., Xie, Q., Yang, F., Huang, J., Fang, D., Huang, Z., Lu, Z., and Chen, Y. Z. (2021a). Preparation of clarithromycin floating core-shell systems (CSS) using multi-nozzle semi-solid extrusion-based 3D printing. International Journal of Pharmaceutics, 605, 120837.

Chen, P., Luo, H., Huang, S., Liu, J., Lin, M., Yang, F., Ban, J., Huang, Z., Lu, Z., Xie, Q., and Chen, Y. Z. (2021b). Preparation of high-drug-loaded clarithromycin gastric-floating sustained-release tablets using 3D printing. AAPS PharmSciTech, 22(3), 131.

Dubin, C. H. (2018). 3D printing – 3D printed drugs hold great potential for personalized medicine. Drug Development & Delivery, 18(2), 50-55.

Dumpa, N. R. Bandari, S., and Repka, M. A. (2020). Novel gastroretentive floating pulsatile drug delivery system produced via hot-melt extrusion and fused deposition modeling 3D printing. Pharmaceutics, 12(1), 52.

FDA, US. (2017). FDA’s role in 3D printing. Food and Drug Administration. [Online URL:] accessed on October 22, 2021.

Freedman, J. (2017). Future Uses and Possibilities of 3D Printing, New York: Cavendish Square Publishing, LLC., pp. 5-25.

Fu, J., Yin, H., Yu, X., Xie, C., Jiang, H., Jin, Y., and Sheng, F. (2018). Combination of 3D printing technologies and compressed tablets for preparation of riboflavin floating tablet-in-device (TiD) systems. International Journal of Pharmaceutics, 549(1-2), 370-379.

Garg, R., and Gupta, G. D. (2008). Progress in controlled gastroretentive delivery systems. Tropical Journal of Pharmaceutical Research, 7(3), 1055-1066.

Giri, B. R., Song, E. S., Kwon, J., Lee, J. H., Park, J. B., and Kim, D. W. (2020). Fabrication of intragastric floating, controlled release 3D printed theophylline tablets using hot-melt extrusion and fused deposition modeling. Pharmaceutics, 12(1), 77.

Gupta, V., Nesterenko, P., and Paull, B. (2019). 3D Printing in Chemical Sciences, London: Royal Society of Chemistry Publishing, pp. 1-21.

Hardung, H., Djuric, D., and Ali, S. (2010). Combining HME & solubilization: Soluplus®—the solid solution. Drug Delivery Technology, 10(3), 20-27.

Hattori, Y., Haruna, Y., and Otsuka, M. (2013). Dissolution process analysis using model-free Noyes-Whitney integral equation. Colloids and Surfaces B: Biointerfaces, 102, 227-231.

Huanbutta, K., and Sangnim, T. (2019). Design and development of zero-order drug release gastroretentive floating tablets fabricated by 3D printing technology. Journal of Drug Delivery Science and Technology, 52, 831-837.

Huanbutta, K., Sriamornsak, P., Kittanaphon, T., Suwanpitak, K., Klinkesorn, N., and Sangnim, T. (2021). Development of a zero-order kinetics drug release floating tablet with anti–flip-up design fabricated by 3D-printing technique. Journal of Pharmaceutical Investigation, 51(3), 213-222.

Jeong, H. M., Weon, K. Y., Shin, B. S., and Shin, S. (2020). 3D-printed gastroretentive sustained release drug delivery system by applying design of experiment approach. Molecules, 25(10), 2330.

Katakam, P., Dey, B., Assaleh, F. H., Hwisa, N. T., Adiki, S. K., Chandu, B. R., and Mitra, A. (2015). Top-down and bottom-up approaches in 3D printing technologies for drug delivery challenges. Critical Reviews™ in Therapeutic Drug Carrier Systems, 32(1), 61-87.

Khaled, S. A., Burley, J. C., Alexander, M. R., Yang, J., and Roberts, C. J. (2015). 3D printing of tablets containing multiple drugs with defined release profiles. International Journal of Pharmaceutics, 494(2), 643-650.

Lin, X., Fu, H., Hou, Z., Si, Y., Shan, W., and Yang, Y. (2021). Three-dimensional printing of gastro-floating tablets using polyethylene glycol diacrylate-based photocurable printing material. International Journal of Pharmaceutics, 603, 120674.

Melocchi, A., Uboldi, M., Inverardi, N., Briatico-Vangosa, F., Baldi, F., Pandini, S., Scalet, G., Auricchio, F., Cerea, M. Foppoli, A., Maroni, A., Zema, L., and Gazzaniga, A. (2019). Expandable drug delivery system for gastric retention based on shape memory polymers: Development via 4D printing and extrusion. International Journal of Pharmaceutics, 571, 118700.

Méndez-Ramos, J., Ruiz-Morales, J. C., Acosta-Mora, P., and Khaidukov, N. M. (2016). Infrared-light induced curing of photosensitive resins through photon up-conversion for novel cost-effective luminescent 3D-printing technology. Journal of Materials Chemistry C, 4(4), 801-806.

Mertz, L. (2013). Dream it, design it, print it in 3-D: What can 3-D printing do for you? IEEE Pulse, 4(6), 15-21.

Öblom, H., Sjöholm, E., Rautamo, M., and Sandler, N. (2019). Towards printed pediatric medicines in hospital pharmacies: Comparison of 2D and 3D-printed orodispersible warfarin films with conventional oral powders in unit dose sachets. Pharmaceutics, 11(7), 334.

Schubert, C., Van Langeveld, M. C., and Donoso, L. A. (2014). Innovations in 3D printing: A 3D overview from optics to organs. British Journal of Ophthalmology, 98(2), 159-161.

Shin, S., Kim, T. H., Jeong, S. W., Chung, S. E., Lee, D. Y., Kim, D. H., and Shin, B. S. (2019). Development of a gastroretentive delivery system for acyclovir by 3D printing technology and its in vivo pharmacokinetic evaluation in Beagle dogs. PLoS One, 14(5), e0216875.

Singpanna, K., Chareonying, T., Patrojanasophon, P., Rojanarata, T., Sukma, M., and Opanasopit, P. (2020). Fabrication of a floating device of domperidone tablets using 3D-printing technologies. Key Engineering Materials, 859, 289-294.

Skowyra, J., Pietrzak, K., and Alhnan, M. A. (2015). Fabrication of extended-release patient-tailored prednisolone tablets via fused deposition modelling (FDM) 3D printing. European Journal of Pharmaceutical Sciences, 68, 11-17.

USP. (2020). Quality of 3D printing of medicines and supplements. The United States Pharmacopeial Convention. [Online URL:] accessed on November 16, 2021.

Ventola, C. L. (2014). Medical applications for 3D printing: Current and projected uses. Pharmacy and Therapeutics, 39(10), 704-711.

Vo, A. Q., Zhang, J., Nyavanandi, D., Bandari, S., and Repka, M. A. (2020). Hot melt extrusion paired fused deposition modeling 3D printing to develop hydroxypropyl cellulose based floating tablets of cinnarizine. Carbohydrate Polymers, 246, 116519.

Wen, H., He, B., Wang, H., Chen, F., Li, P., Cui, M., Li, Q., Pan, W., and Yang, X. (2019). Structure-based gastro-retentive and controlled-release drug delivery with novel 3D printing. AAPS PharmSciTech, 20(2), 68.

Whitehead, L., Fell, J. T., Collett, J. H., Sharma, H. L., and Smith, A. M. (1998). Floating dosage forms: an in vivo study demonstrating prolonged gastric retention. Journal of Controlled Release, 55(1), 3-12.

Zhang, P., Shadambikar, G., Almutairi, M., Bandari, S., and Repka, M. A. (2020). Approaches for developing acyclovir gastro-retentive formulations using hot melt extrusion technology. Journal of Drug Delivery Science and Technology, 60, 102002.