Recent advances in 3D printing for floating drug delivery platforms
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Abstract
Floating drug delivery is a gastro-retentive delivery system offering an advantage for poor-bioavailability drugs, which have low absorption in the upper gastrointestinal tract. This system can be administered effectively, increasing bioavailability and optimizing absorption. This technique can also prolong drug release, resulting in less frequent drug administration throughout the day. However, key restrictions of floating drug delivery are the ability to change drug dosage, drug release kinetics, buoyant force, and duration to suit each patient. With the constraints of the conventional manufacturing process, 3D printing has been developed to produce floating drug delivery devices with flexible dosage forms. This review summarizes studies that used different 3D printing techniques and materials to produce their own floating drug delivery systems and also discuss the limitation of this manufacturing technique.
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