Design and evaluation of double coated floating capsules based on gas formation
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Abstract
The purpose of this work was to create double coated floating capsules using gas formation. Theophylline was used as a model drug. Theophylline and hydroxypropyl methylcellulose (HPMC) were physically blended and filled in hard capsules. Then, they were coated with a layer of a gas producing agent (NaHCO3) and a gas- entrapped membrane. The impact of types of gel-forming polymers, and gas-entrapped membrane's coating types and levels on floating characteristics and drug release from the floating capsules was investigated. Optimum formulations could float immediately and maintain buoyancy longer than 8 h. The increased viscosity of the high molecular weight HPMC in the floating capsules resulted in a delayed drug release, compared to the low molecular weight HPMC-containing capsules. The floating capsules coated with EuRS30D released the drug more slowly than those coated with EuRL30D. Due to EuRS30D demonstrated relatively low drug release, EuRL30D appeared to be a promising option for gas-entrapped membranes. Drug release was decreased as the gas-entrapped membrane's coating level was increased, resulting from a thicker film. The floating capsules with good floating abilities and sustained drug release were obtained in this investigation.
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