Development of fast dissolving orodispersible films loaded with cannabis extract
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Abstract
Nowadays, cannabis plants are currently authorized to be used legally in Thailand for medical purposes. The current dosage form of cannabis extract is oil for sublingual drops. However, there are lots of limitations to these forms, including difficulty in administering, carrying, volume control, and the stability of the extract. Therefore, oral disintegrating films loaded with cannabis extract were developed to minimize the limitations of conventional dosage forms. The extraction process of cannabis leaves was conducted by the reflux technique, using ethanol as the solvent. The major compounds, cannabidiol (CBD) and tetrahydrocannabinoid (THC), from cannabis leaf extract were analyzed. The results showed that the crude extract contained CBD and THC concentrations of 2.45 mg and 9.93 mg per 100 g of the crude extract, respectively. The optimized formulation for oral disintegrating films was 2.5% hydroxypropyl methylcellulose, 1.5% propylene glycol, and 2.11% cannabis extract. The prepared films could disintegrate in 20 s when tested by the disintegration tester. Mechanical properties testing revealed that the film was strong and flexible. All of the experiments revealed that the oral disintegrating film containing cannabis extract had the potential to be commercialized and utilized instead of the conventional dosage forms.
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