ฤทธิ์ในการยับยั้ง Candida sp. ของ Cinnamaldehyde ร่วมกับ Fluconazole ในหลอดทดลอง
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Abstract
The aim of this study was to determine the antifungal effect of cinnamaldehyde with fluconazole against Candida sp. in vitro. The minimum inhibitory concentrations (MIC) and minimum fungicidal concentrations (MFC) of cinnamaldehyde and fluconazole against C. tropicalis U624/10, C. glabata U71/11, C. parapsilosis ATCC 22019 and C. albicans U821/10 were determined. The effect of cinnamaldehyde in combination with fluconazole against Candida sp. was evaluated by chequerboard microtiter technique. The MIC of fluconazole against C. tropicalis U624/10, C. glabata U71/11, C. parapsilosis ATCC 22019 and C. albicans U821/10 were 128, 128, 1 and 0.25 µg/ml, respectively. The MIC and MFC for cinnamaldehyde against 4 stains of Candida sp. were 125 µg/ml. By using chequerboard microtiter technique, the combination of cinnamaldehyde with fluconazole against C. glabata U71/11, C. parapsilosis ATCC 22019 and C. albicans U821/10 showed indifferent. While, antagonistic activity was observed against C. tropicalis U624/10. It can be concluded that cinnamaldehyde was failed to synergize with fluconazole against Candida spices in vitro.
Keywords: cinnamaldehyde; fluconazole; Candida sp.
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