ฤทธิ์ทางชีวภาพของสารเบอร์บีรีนที่แยกจากเถาแห้ม

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ชุติมา แก้วพิบูลย์
ณวงศ์ บุนนาค

Abstract

Berberine from crude methanol extract of Coscinium fenestratum stem was purified by column chromatography using methanol : acetic acid : water solvent system (13 : 0.7 : 1). The berberine structure was elucidated by spectroscopic techniques. After that, the biological activities of berberine were investigated, including α-glucosidase and amylase inhibitory activities, antioxidant activities, and cytotoxicity against human lung cancer cell line A549. We found that berberine showed effective cytotoxicity against A549 cell line with an IC50 value of 20.33±3.51 μg/mL. Therefore, this study provided important information for a promising lead compound for of anticancer drug development.

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Section
วิทยาศาสตร์ชีวภาพ
Author Biographies

ชุติมา แก้วพิบูลย์

สาขาวิชาชีววิทยา คณะวิทยาศาสตร์ มหาวิทยาลัยทักษิณ วิทยาเขตพัทลุง ตำบลบ้านพร้าว อำเภอป่าพะยอม จังหวัดพัทลุง 93210

ณวงศ์ บุนนาค

สาขาวิชาวิทยาศาสตร์และคณิตศาสตร์พื้นฐาน คณะวิทยาศาสตร์ มหาวิทยาลัยทักษิณ ตำบลเขารูปช้าง อำเภอเมือง จังหวัดสงขลา 90000

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