Deoxynivalenol

Abstract

Deoxynivalenol (DON) is a derivative of trichothecenes type B, which is generally detected in numerous types of cereal that contaminated with Fusarium spp., especially Fusarium roseum, Fusarium culmorum, and Fusarium graminearum. DON was classified by International Agency for Research on Cancer (IARC) as a group 3 (not classifiable as its carcinogenicity to humans). However, DON can cause gastrointestinal disorders, nausea, diarrhea, vomiting, abdominal pain, headache, and fever in humans. Exposure to DON may cause gastrointestinal disorders, nausea, vomiting, abdominal pain, diarrhea, headache, and fever in humans. In the case of an animal, DON causes immunosuppression, and liver and kidney damages. The aim of this review was to describe the background of DON, including its discovery, occurrence, toxicity, decontamination strategies, and worldwide mycotoxin regulation.