Deoxynivalenol

Article Sidebar

PDF
Published: Jan 27, 2022
Keywords:
Mycotoxin Deoxynivalenol Mycotoxin decontamination Mycotoxin regulation

Main Article Content

Saowalak Adunphatcharaphon
School of Food Science and Technology, Faculty of Science and Technology, Thammasat University, Pathum Thani 12120
Awanwee Petchkongkaew
School of Food Science and Technology, Faculty of Science and Technology, Thammasat University, Pathum Thani 12120
Warissara Kasikonsunthonchai
School of Food Science and Technology, Faculty of Science and Technology, Thammasat University, Pathum Thani 12120

Abstract

Deoxynivalenol (DON) is a derivative of trichothecenes type B, which is generally detected in numerous types of cereal that contaminated with Fusarium spp., especially Fusarium roseum, Fusarium culmorum, and Fusarium graminearum. DON was classified by International Agency for Research on Cancer (IARC) as a group 3 (not classifiable as its carcinogenicity to humans). However, DON can cause gastrointestinal disorders, nausea, diarrhea, vomiting, abdominal pain, headache, and fever in humans. Exposure to DON may cause gastrointestinal disorders, nausea, vomiting, abdominal pain, diarrhea, headache, and fever in humans. In the case of an animal, DON causes immunosuppression, and liver and kidney damages. The aim of this review was to describe the background of DON, including its discovery, occurrence, toxicity, decontamination strategies, and worldwide mycotoxin regulation. 

Article Details

Issue
Vol.30 No.1 (January - February 2022)
Section
Biological Sciences

References

BIOMIN, 2020, World Mycotoxin Survey Q2 2020, Austria.

Pierron, A., Mimoun, S., Murate, L.S., Loiseau, N., Lippi, Y., Bracarense, A.P., Liaubet, L., Schatzmayr, G., Berthiller, F., Moll, W.D., and Oswald, I.P., 2016, Intestinal toxicity of the masked mycotoxin deoxynivalenol-3-β-D-glucoside, Arch Toxicol. 90: 2037-46.

Bryden, W.L., 2012, Mycotoxin contamination of the feed supply chain: implications for animal productivity and feed security, Animal Feed Sci. Technol. 173: 134-158.

Sobrova, P., Adam, V., Vasatkova, A., Beklova, M., Zeman, L., and Kizek, R., 2010, Deoxynivalenol and its toxicity. Interdiscip. Toxicol. 3(3): 94-99.

Yoshizawa, T., Takeda, H., and Ohi T., 1983, Structure of a novel metabolite from deoxynivalenol, a trichothecene mycotoxin, in animals. Agr. Biol. Chem. 47: 2133-2135.

Yoshizawa, T, and Morooka, N., 1973, Deoxynivalenol and its monoacetate – New mycotoxins from Fusarium roseum

and moldy barley. Agr. Biol. Chem. 37:2933-2934.

Ueno, Y., 1988, Toxicology of trichothecene mycotoxins. ISI Atlas Sci-Pharm.2: 121-124.

Morooka, N., and Yoshizawa, T, 1973,Deoxynivalenol and its acetate: new mycotoxins from Fusarium roseum and moldy barley, Agric. Biol. Chem. 37: 2933-2934.

Ueno, Y., 1985, The toxicology of mycotoxins. CRC Crit. Rev. Toxicol. 14: 99–132.

EFSA, 2013a, Statement on the risks for public health related to a possible increase of the maximum level of deoxynivalenol for certain semi-processed cereal products. EFSA Journal. 11(12): 3490.

Kostelanska, M., Dzuman, Z., Malachova, A., Capouchova, I., Prokinova, E., Skerikova, A., and Hajslova, J., 2011, Effects of

milling and baking technologies on levels of deoxynivalenol and its masked form deoxynivalenol-3-glucoside. J. Agric. Food Chem. 59(17): 9303-9312.

IARC, 1993, IARC monographs on the evaluation of carcinogenic risks to humans. Some naturally occurring sub-stances: Food items and constituents, heterocyclic aromatic amines and mycotoxins. International Agency for Research on Cancer, Volume 56, Lyon, France.

Pestka, J.J., 2008a, Mechanisms of deoxynivalenol-induce gene expression and apoptosis. Food Addit. Contam. Part A Chem. Anal. Control Expo Risk Assess. 25: 1128-1140.

Pestka, J.J., 2007b, Deoxynivalenol: toxicity, mechanisms and animal health risks. Anim. Feed Sci. Technol. 137(3-4):0-298.

Yao, Y., and Long, M., 2020, The biological detoxification of deoxynivalenol: A review. Food Chem. Toxicol. 145: 111649.

Sharma, A., 1998, Mycotoxins: risk evaluation and management in radiation-processed foods, in Sinha K. and Bhatnagar. D., Mycotoxins in Agriculture and Food Safety, New York, Marcel Dekker Inc., 435-57.

Polak-Śliwińska, M., and Paszczyk, B., 2021. Trichothecenes in Food and Feed, Relevance to Human and Animal Health

and Methods of Detection: A Systematic Review. Molecules. 26(2): 454.

Sugita-Konishi Y., and Kimura M., 2013, Nivalenol (Fungal Sesquiterpenes). In: Ramawat K., Mérillon JM. (Eds.) Natural Products. Springer, Berlin, Heidelberg.

Eskola, M., Kos, G., Elliott, C.T., Hajšlová, J., Mayar, S., and Krska, R., 2019, Worldwide contamination of food-crops with mycotoxins: Validity of the widely cited‘FAO estimate' of 25, Crit. Rev. Food Sci. Nutr. 60(16): 2773-2789.

EFSA, 2017b, Opinion of the Scientific Panel on Contaminants in the Food Chain (CONTAM Panel) on the risks to human and animal health related to the presence of deoxynivalenol and its acetylated and modified forms in food and feed. European Food Safety Authority. EFSA Journal. 15: 4718.

EFSA, 2017c, Scientific report on human and animal dietary exposure to ergot alkaloids. European Food Safety Authority. EFSA Journal. 15: 4902.

Wang, G., Wang, T., Ji, F., Xu, L., Tu, M., Shi, J., and Xu, J., 2019, Biodegradation of deoxynivalenol and its derivatives by Devosia insulae A16, Food Chem. 276:436-442.

Kos, J., Hajnal, J.E., Saric, B. Jovanov, P., Nedeljkovic, N., Milovanovic, I. and Krrulj, J., 2017, The influence of climate conditions on the occurrence of deoxynivalenol in maize harvested in Serbia during 2013 - 2015. Food Control. 73: 734 - 740.

Gruber-Dorninger, C., Jenkins, T., and Schatzmayr, G., 2019. Global mycotoxin occurrence in feed: A ten-year survey. Toxins. 11(7): 375.

Chen, C., Turna, S. N., and Wu, F., 2019. Risk assessment of dietary deoxynivalenol exposure in wheat products worldwide: Are new codex DON guidelines adequately protective?. Trends in Food Science & Technology. 89: 11-25.

Charoenpornsook, K., and Kavisarasai, P. 2006. Mycotoxins in animal feedstuffs of Thailand. KMITL Sci. Tech. 6(1).

BIOMIN, 2019, World Mycotoxin Survey 2019, Austria.

กระทรวงสาธารณสุข. ประกาศกระทรวง สาธารณสุข (ฉบับที่ 414) พ.ศ. 2563 เรื่อง มาตรฐานอาหารที่มีสารปนเปื้อน. ราชกิจจานุเบกษา ฉบับประกาศทั่วไป เล่มที่ 137, ตอนพิเศษ 118 ง (ลงวันที่ 20 พฤษภาคม 2563).

FAO, 2015, The State of Agricultural Commodity Markets 2015-2016, Trade and food security: Achieving a better balance between national priorities and the collective good. Food and Agriculture Organization of the United Nations, Rome. Available Source: http://www.fao.org/publications/soco/the-state-of-agricultural-commodity-markets-2015-16/en/, January, 27, 2021.

Anukul, N., Vangnai, K., and Mahakarnchanakul, W., 2013, Significance of regulation limits in mycotoxin contamination in Asia and risk management programs at the national level, J. Food Drug Anal. 21:227-241.

Hooshmand, H., and Klopfenstein, C. F.,1995, Effect of gamma-irradiation on mycotoxin disappearance and amino-acid contents of corn, wheat, and soybeans with different moisture contents, Plant Food Hum. Nutr. 47(3): 227-238.

Aziz, N.H., Attia, E.S.A., and Farag, S.A., 1997, Effect of gamma-irradiation on the natural occurrence of Fusarium mycotoxins in wheat, flour and bread, Nahrung Food. 41(1): 34-7.

Magan, N. and Olsen, M., 2004, Mycotoxins in food: Detection and control. Woodhead Publishing Ltd. USA. p. 471.

Cazzaniga, D., Basílico, J.C., González, R.J., Torres, R.L., and De Greef, D.M., 2001, Mycotoxins inactivation by extrusion cooking of corn flour. Lett. Appl. Microbiol. 33(2): 144-147.

Lopez-Garcia, R., Park, D.L., and Phillips, T.D., 1999, Integrated mycotoxin management systems. In Preventing Mycotoxins Contamination, FAO Food and Nutrition Division, FNA/ANA 23: 38-47.

Sun, X., Ji, J., Gao, Y., Zhang, Y., Zhao, G., and Sun, C., 2020, Fate of deoxynivalenol and degradation products degraded by aqueous ozone in contaminated wheat.Food Res. Int. 137: 109357.

Swanson, S.P., Hagler, W.M. and Rood, H.D., 1984, Destruction of deoxynivalenol (vomitoxin) with sodium bisulfite (abstr.), Ann. Meet. Am. Soc. Microbiol. 84: 192.

Larsena, J.C., Huntb, J., Perrinc, I., and Ruckenbauerd, P., 2004, Workshop on trichothecenes with a focus on DON: summary report. Toxicol. Lett. 153: 1-22.

Sato, I., Ito, M., Ishizaka, M., Ikunaga, Y., Sato, Y., Yoshida, S., Koitabashi, M., and Tsushima, S., 2012, Thirteen novel deoxynivalenol degrading bacteria are classified within two genera with distinct degradation mechanisms. FEMS Microbiol. Lett. 327(2): 110-117.

El-Nezami, H.S., Chrevatidis, A., Auriola, S., Salminen, S., and Mykkanen, H., 2002, Removal of common Fusarium toxins in vitro by strains of Lactobacillus and Propionibacterium. Food Addit. Contam. 19(7): 680-686.

Niderkorn, V., Boudra, H., and Morgavi, D.P., 2006, Binding of Fusarium mycotoxins by fermentative bacteria in vitro. J. Appl. Microbiol. 101(4): 849-856.

Foroud, N.A., Baines, D., Gagkaeva, T.Y., Thakor, N., Badea, A., Steiner, B., Bürstmayr, M., and Bürstmayr, H., 2019, Trichothecenes in Cereal Grains – An Update. Toxins, 11(11): 634. Available Source: https://www.mdpi.com/2072-6651/11/11/634, March 22, 2021.

Zhang, J., Qin, X., Guo, Y., Zhang, Q., Ma, Q., Ji, C., and Zhao, L, 2020, Enzymatic degradation of deoxynivalenol by a novel bacterium, Pelagibacterium halotolerans ANSP101. Food Chem. Toxicol. 140: 111276.