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Wisumpayayai is an herbal remedy which has been used as anti-flatulence and anti-dyspepsia medication. This study aimed to investigate the effect of the ethanol extract of Wisumpayayai remedy on phagocytosis, nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression in lipopolysaccharide-activated J774A.1 macrophage. The extract 12.5-100 µg/ml significantly decreased phagocytic activity of the activated macrophage in a concentration-dependent manner. The extract also suppressed nitric oxide production in these cells with the IC50 value of 37.39 µg/ml. The expression of inducible nitric oxide synthase which is responsible for NO production in activated macrophage during inflammation was decreased by the extract 50-100 µg/ml. The results obtained from this study indicated that Wisumpayayai ethanol extract are able to inhibit macrophage functions. This remedy may have other potential pharmacological properties beyond anti-flatulence and anti-dyspepsia effects.
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