A Comparison of the Potency of Dopamine Antagonists on Spawning Induction in Thai Carp (Puntius gonionotus Bleeker)

Abstract

The potency of three dopamine antagonists (DA) i.e., domperidone (DOM), sulpiride (SUL), and metoclopramide (MET) on spawning induction in Thai carp was compared. Sexually mature female Thai carp were injected with DOM, SUL or MET at concentrations of 5, 10, 20 or 40 mg/kg alone or in combination with the LHRH analog Buserelin (BUS) at 5 or 20 μg/kg and were allowed to spawn naturally. The results of the study showed that the three DA had the same potency when used alone. When used in combination with BUS at either low or high dosage, the order of potency of the three DA was 5 mg/kg DOM = 20 mg/kg MET = 40 mg/kg SUL. It was concluded that DOM had the highest potency on the spawning induction of the Thai carp. However, it was recommended to use 20 mg/kg MET in combination with 5 μg/kg BUS to induce spawning of mature female Thai carp, when both potency and cost were considered.