Assay of Acetaminophen in Paracetamol Tablets by Differential Pulse Voltammetry

Authors

  • Duncan Thorburn Burns Department of Analytical Chemistry, The Queen’s University of Belfast BT9 5AG UK.
  • Nipon Tungkananuruk Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.
  • Sumaporn Kasemsumran Department of Chemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.
  • Kanita Tungkananuruk Department of Chemistry, Faculty of Science, King Mongkut’s Institute of Technology, Lardkrabang, Bangkok 10520, Thailand.

Keywords:

acetaminophen, paracetamol, differential pulse voltammetry, glassy carbon electrode

Abstract

A simple and precise procedure using differential pulse voltammetry was developed for the assay of acetaminophen in paracetamol tablets. The peak current from acetaminophen in 0.1 mol L-1 phosphate buffer pH 7.0 was measured using a glassy carbon electrode and a Ag/AgCl reference electrode. The optimum step potential and modulation amplitude were 0.0020 and 0.0500 V, respectively. The linear calibration range was 0-300 μg ml-1, the detection limit and recovery were 0.15 μg ml-1 and 99.4%, respectively. The results were compared with those obtained by the U.S.P XXII official method.

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Published

2004-08-30

How to Cite

Duncan Thorburn Burns, Nipon Tungkananuruk, Sumaporn Kasemsumran, and Kanita Tungkananuruk. 2004. “Assay of Acetaminophen in Paracetamol Tablets by Differential Pulse Voltammetry”. Agriculture and Natural Resources 38 (4). Bangkok, Thailand:510-14. https://li01.tci-thaijo.org/index.php/anres/article/view/243200.

Issue

Vol. 38 No. 4 (2004): July-August

Section

Research Article

License

online 2452-316X print 2468-1458/Copyright © 2022. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/),
production and hosting by Kasetsart University of Research and Development Institute on behalf of Kasetsart University.