Monte Carlo Cellular Automata Simulation of Receptor Trafficking in Cell Signal Transduction: Tracking Dimer and Oligomer Formation

Authors

  • Chontita Rattanakul Department of Mathematics, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
  • Yongwimon Lenbury Centre of Excellence in Mathematics, CHE, 328 Si Ayutthaya Road, Bangkok 10400, Thailand.

Keywords:

signal transduction, cellular automata, receptor trafficking, dimerization

Abstract

A cellular automata (CA) model of the signal transduction pathway mediated by calcium sensing (CaS) receptors was constructed to investigate the effects of different fractions of healthy (functional) and defective receptors. Receptor trafficking was allowed to take place leading to dimerization and oligomerization which exerted a positive impact on the receptor binding affinity. Snapshots of receptor trafficking and distribution over the cell membrane simulated by the CA model were compared with the no-trafficking case. 

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Published

2015-12-31

How to Cite

Rattanakul, Chontita, and Yongwimon Lenbury. 2015. “Monte Carlo Cellular Automata Simulation of Receptor Trafficking in Cell Signal Transduction: Tracking Dimer and Oligomer Formation”. Agriculture and Natural Resources 49 (6). Bangkok, Thailand:1036-46. https://li01.tci-thaijo.org/index.php/anres/article/view/243822.

Issue

Vol. 49 No. 6 (2015): November-December

Section

Research Article

License

online 2452-316X print 2468-1458/Copyright © 2022. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/),
production and hosting by Kasetsart University of Research and Development Institute on behalf of Kasetsart University.