Monte Carlo Cellular Automata Simulation of Receptor Trafficking in Cell Signal Transduction: Tracking Dimer and Oligomer Formation

ผู้แต่ง

  • Chontita Rattanakul Department of Mathematics, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
  • Yongwimon Lenbury Centre of Excellence in Mathematics, CHE, 328 Si Ayutthaya Road, Bangkok 10400, Thailand.

คำสำคัญ:

signal transduction, cellular automata, receptor trafficking, dimerization

บทคัดย่อ

A cellular automata (CA) model of the signal transduction pathway mediated by calcium sensing (CaS) receptors was constructed to investigate the effects of different fractions of healthy (functional) and defective receptors. Receptor trafficking was allowed to take place leading to dimerization and oligomerization which exerted a positive impact on the receptor binding affinity. Snapshots of receptor trafficking and distribution over the cell membrane simulated by the CA model were compared with the no-trafficking case. 

ดาวน์โหลด

เผยแพร่แล้ว

2015-12-31

รูปแบบการอ้างอิง

Rattanakul, Chontita, และ Yongwimon Lenbury. 2015. “Monte Carlo Cellular Automata Simulation of Receptor Trafficking in Cell Signal Transduction: Tracking Dimer and Oligomer Formation”. Agriculture and Natural Resources 49 (6). Bangkok, Thailand:1036-46. https://li01.tci-thaijo.org/index.php/anres/article/view/243822.

ฉบับ

ปีที่ 49 ฉบับที่ 6 (2015): November-December

ประเภทบทความ

Research Article

สัญญาอนุญาต

online 2452-316X print 2468-1458/Copyright © 2022. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/),
production and hosting by Kasetsart University of Research and Development Institute on behalf of Kasetsart University.