ATR-FTIR and GC-MS Methods for Detection of Sibutramine Adulterated in Slimming Products of Instant Coffee

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Sitanan Parameesrijanya
Sirirat Choosakoonkriang
Supachai Supalaknari
Piyapa Junmon


One of the most common adulterants: Sibutramine has been found in slimming products. This work aimed to study the application of attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and gas chromatography coupled with mass spectrometry (GC-MS) to detect sibutramine in slimming products in the form of Instant coffee. Twenty instant coffee products were acquired from local markets and online stores. At wavenumber 4000-650 cm-1, ATR-FTIR analysis was performed. The mass spectra of the sample indicate a distinct peak for sibutramine. The screening test obtained by ATR-FTIR could be confirmed by GC-MS. The screening was performed on selected ion monitoring mode at 58, 72, and 114 amu (Sibutramine) at a retention time 23.997 minute. Furthermore, laxatives (Bisacodyl) were detected in samples evaluated by GC-MS at a retention time 36.534 minute, while antibiotic (Paromomycin) were detected at a retention time 6.089 minute. This is qualitative investigation using ATR-FTIR and GC-MS to discover sibutramine adulterated in instant coffee slimming products. Both techniques are capable of detecting sibutramine in slimming Instant coffee, which could be useful in forensic examination. 

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How to Cite
Parameesrijanya, S. ., Choosakoonkriang, S. ., Supalaknari, S., & Junmon, P. . (2022). ATR-FTIR and GC-MS Methods for Detection of Sibutramine Adulterated in Slimming Products of Instant Coffee. Rajamangala University of Technology Tawan-Ok Research Journal, 15(1), 41–49. Retrieved from
Research article
Author Biographies

Sitanan Parameesrijanya, Silpakorn University

Faculty of Science

Sirirat Choosakoonkriang, Silpakorn University

Faculty of Science

Supachai Supalaknari, Silpakorn University

Department of Chemistry, Faculty of Science

Piyapa Junmon, Silpakorn University

Department of Chemistry, Faculty of Science


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