Antioxidant Activity and Cytotoxicity against Human Cancer Cell Lines of the Aqueous Leaf Extracts of Smilax luzonensis, Hoya kerrii and Derris elliptica
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Abstract
This study aimed to evaluate the antioxidant activity and cytotoxic effect against various human cancer cell lines including HepG2, Jurkat and MCF-7 of the water leaf extracts of Smilax luzonensis (SLE), Hoya kerrii (HKE) and Derris elliptica (DEE). The extracts were used to evaluate total phenolics content (TPC), total flavonoids content (TFC), and antioxidant activity by using FRAP and DPPH assays. They were also tested for in vitro cytotoxic effect on human cancer cell lines by MTT assay. The results showed that the highest TPC, TFC and antioxidant activity were found in DEE, followed by SLE and HKE, respectively. DEE exhibited higher cytotoxicity to all tested human cancer cell lines than SLE and HKE, respectively. DEE showed the highest cytotoxic activity against jurkat (IC50= 0.20 mg/mL), followed by MCF-7 (IC50 = 0.42 mg/mL) and HepG2 (IC50= 0.76 mg/mL), respectively. Pearson’s correlation analysis indicated that TPC and TFC related to antioxidant activities of the extracts. The results suggested that DEE possessed high contents of TPC and TFC, thus having high antioxidant potential and cytotoxicity to all tested human cancer cell lines.
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บทความที่ได้รับการตีพิมพ์เป็นลิขสิทธิ์ของ วารสารวิทยาศาสตร์และเทคโนโลยี มหาวิทยาลัยอุบลราชธานี
ข้อความที่ปรากฏในบทความแต่ละเรื่องในวารสารวิชาการเล่มนี้เป็นความคิดเห็นส่วนตัวของผู้เขียนแต่ละท่านไม่เกี่ยวข้องกับมหาวิทยาลัยอุบลราชธานี และคณาจารย์ท่านอื่นๆในมหาวิทยาลัยฯ แต่อย่างใด ความรับผิดชอบองค์ประกอบทั้งหมดของบทความแต่ละเรื่องเป็นของผู้เขียนแต่ละท่าน หากมีความผิดพลาดใดๆ ผู้เขียนแต่ละท่านจะรับผิดชอบบทความของตนเองแต่ผู้เดียว
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