Development of an electrochemical sensor based on hemin modified screen-printed carbon electrode for the determination of artemisinin
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Abstract
An electrochemical sensor for the determination of artemisinin (ARN) using hemin modified screen-printed carbon electrode (SPE) has been developed. Hemin can induce the electro-catalytic reduction of artemisinin. The modified electrode was characterized by physical and electrochemical techniques such as scanning electron microscopy (SEM), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The calibration graph obtained from Hemin/SPE for the detection of artemisinin was over the range from 5.6 μM to 0.1 mM with a detection and quantitation limit of 1.4 μM (S/N = 3) and 4.5 μM (S/N =10). Moreover, the proposed sensor showed good repeatability and reproducibility at 1.6 and 4.4 %RSD, respectively. The application for real drug and plant samples were obtained the average recovery percentage in the range of 98.7 – 106.8% and the results agreed with HPLC reference technique. These indicated that the proposed electrochemical sensor could be applied for detection of artemisinin in real samples with good precision and accuracy, cheap and reliability.
Article Details
บทความที่ได้รับการตีพิมพ์เป็นลิขสิทธิ์ของ วารสารวิทยาศาสตร์และเทคโนโลยี มหาวิทยาลัยอุบลราชธานี
ข้อความที่ปรากฏในบทความแต่ละเรื่องในวารสารวิชาการเล่มนี้เป็นความคิดเห็นส่วนตัวของผู้เขียนแต่ละท่านไม่เกี่ยวข้องกับมหาวิทยาลัยอุบลราชธานี และคณาจารย์ท่านอื่นๆในมหาวิทยาลัยฯ แต่อย่างใด ความรับผิดชอบองค์ประกอบทั้งหมดของบทความแต่ละเรื่องเป็นของผู้เขียนแต่ละท่าน หากมีความผิดพลาดใดๆ ผู้เขียนแต่ละท่านจะรับผิดชอบบทความของตนเองแต่ผู้เดียว
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