α-Glucosidase inhibitory activity of benzophenones and xanthones from the ripe fruits of Garcinia cowa Roxb. ex.DC.
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Abstract
Phytochemical investigation of Cha-muang (Garcinia cowa Roxb. ex DC.) ripe fruits led to the isolation and identification of two benzophenones; garcicowin B (1) and oblongifolin C (2), and three xanthones; brasixanthone B (3), 9-hydroxycalabaxanthone (4) and 3-O-methylmangostenone D (5). The structures of these five known isolated compounds were elucidated based on spectroscopic methods (UV, IR, and 1H-NMR) as well as comparison with previous reported data in literatures. All these isolates were evaluated for their inhibitory effects on α-glucosidase. Results indicated that compounds 4 and 5 showed potent α-glucosidase inhibitory activities with IC50 values of 63.41 ± 1.26 and 87.16 ± 0.35 ug/ml, respectively.
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