Bioactive Compound, Antioxidant and Alpha glucosidase inhibitory Activities of Tot mu tot ma (Paederia linearis Hook. f.)

Abstract

The aims of this study were to study bioactive compounds, antioxidant and alpha glucosidase inhibitory activites of Tot mu tot ma (Paederia linearis) root, stem and leaves crude extract. The maceration method was used with ethanol solvents. Total phenolic and flavonoid content of various extract were determined by standard methods. Investigation of antioxidant activites included 2,2-diphenyl-1-picrylhydrazyl (DPPH) and Ferric reducing antioxidant power (FRAP). In vitro α-glucosidase inhibitory assays, respectively.  The ethanolic leaf extracts had the highest total phenolic content (174.42±2.07 mgGAE.g-¹) and flavonoids content (41.32±1.94 mgQE.g^-1). Antioxidant activity in leaf extracts were highest in testing methods, i.e. DPPH free radical scavenging method (40.73 ± 6.68 %) and Ferric reducing antioxidant power (21.35 ± 5.80 mMFe.g^-1) respectively. In addition, the leaf of P. linearis revealed highest alpha glucosidase inhibitory at 93.04±1.63 %. The results suggest that the leaf extract of P. linearis  has may be used to treat type 2 diabetes.