Effects of Abutilon indicum (L.) Sweet and Pavonia rigida (Wall. ex Mast.) Hochr. Root Extracts on Serum Lipid Profiles of Ovariectomized Rats

บทคัดย่อ

The objectives of this research were to study the effects of ethanolic root extracts of Country mallow (Abutilon indicum (L.) Sweet and Cocklebur (Pavonia rigida (Wall. ex Mast.) Hochr. on serum lipid levels and quantities of flavonoid and total phenolic compounds. Ovariectomized (OVX) Wistar rats were fed with the two extracts at the dose of 500 mg/kg body weight everyday for fourteen days. The results showed that both A. indicum and P. rigidaextracts result in significant decrease of total cholesterol, a low-density lipoprotein. but, their extracts result in significant increase of high-density lipoprotein levels of OVX rats compared with their OVX control (p<0.05). However, the triglyceride level in serum was increased significantly (p< 0.05). The flavonoid and total phenolic compounds in Country mallow were 57.62 ± 0.04 mg QE/100mg and 41.05 ± 1.18 mg GAE/100 mg respectively and in Cocklebur were 59.17 ± 0.04 mg QE/100 mg and 57.17 ± 2.11 mg GAE/100 mg respectively. These results indicate that the root extracts from A. indicum and P. rigida possess hypolipiclemic activity and this activity is more likely associated with the presence of flavonoid and total phenolic compounds.