Induction of External Infection-models in Experimental Animals: A review

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Nitima Tatiya-aphiradee


Infection remains a leading cause of mortality and economic loss. Development of a new effective antimicrobial agent to combat infection is necessary. In vitro testing is investigated for basic potential, but it is insufficient to assure efficiency and efficacy of an antimicrobial agent. Hence, in vivo testing has been recognized as the essential study to provide reliable information and to support the in vitro data. This review aims to summarize models for the induction of external infections in experimental animals and categorize by the principles and equipment of the wound inductions, appearance of the wounds, and strains and species of animals, and microorganisms employed. The induction of external infection models in animals is divided into 5 categories including skin abrasion infection model, burn wound infection model, foreign body infection model, lacerated wound infection model and excisional wound infection model. Thus, the optimal wound induction model depends on the aim(s) of a study and consideration criteria of a researcher to gain the informative and applicable data.


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