Biological Activities of Curcuma zedoaria (Christm.) Roscoe
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Abstract
Curcuma zedoaria is a medicinal plant belonging to the family of Zingiberaceae which contains active compounds as curcuminoids. Moreover, C. zedoaria shows a wide range of biological activities. Therefore, the aim of this research was to study biological activities of C. zedoaria extracted by ethanol. The results were shown that crude extract exhibited total phenolic compounds of 84.32.2.21 mg GAE/g extract. The antioxidant activities assay by DPPH and ABTS method showed EC50 values of 150.00±10.00 and 110.00±5.21 µg/mL, respectively. In addition, the crude extract showed the inhibitory activity of tyrosinase with IC50 values of 102.5±38.89 µg/mL. Furthermore, ethanol crude extract of C. zedoaria non-cytotoxicity against HaCaT cell lines showed IC50 values more than 200 µg/mL. Therefore, it is very interesting for the development of the C. zedoaria extract as a diverse cosmeceutical, medicinal and food additives applications.
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References
Zhou, L., Zhang, K., Li, J., Cui, X., Wang, A., Huang, S., Zheng, S., Lu, Y. and Chen, W., 2013, Inhibition of vascular endothelial growth factor-mediated angiogenesis involved in reproductive toxicity induced by sesquiterpenoids of Curcuma zedoaria in rats. Reprod Toxicol. 37: 62-9.
Angel, G.R., Menon, N., Vimala, B. and Nambisan, B., 2014, Essential oil composition of eight starchy Curcuma species. Ind. Crops Prod. 60: 233–238.
Lobo, R., Prabhu, K.S. and Shirwaikar, A., 2009, Curcuma zedoaria Rosc (white turmeric): A review of its chemical, pharmacological and ethnomedicinal properties. J. Pharm. Pharmacol. 61:13–21.
Seo, W.G., Hwang, J.C., Kang, S.K., Jin, U.H., Suh, S.J., Moon, S.K. and Kim, C.H., 2005, Suppressive effect of Zedoariae rhizome on pulmonary metastasis of B16 melanoma cells. J. Ethnopharmacol. 101:249–257.
Makabe, H., Maru, N., Kuwabara, A., Kamo, T. and Hirota, M., 2006, Anti-inflammatory sesquiterpenes from Curcuma zedoaria. Nat. Prod. Res. 20: 680–685.
Wilson, B., Abraham, G., Manju, V.S., Mathew, M., Vimala, B., Sundaresan, S. and Nambisan, B., 2005, Antimicrobial activity of Curcuma zedoaria and Curcuma malabarica tubers. J. Ethnopharmacol. 99: 147–151
Singh, P., Singh, S., Kapoor, I.P.S., Singh, G., Isidorov, V. and Szczepaniak, L., 2013, Chemical composition and antioxidant activities of essential oil and oleoresins from Curcuma zedoaria rhizomes. Food Biosci. 3: 42–48.
Bridson, D. and Forman, L., 1992., The Herbarium Handbook. 3rd ed. Kew, UK: Royal Botanic Gardens.
Doyle, J. and Doyle, J., 1987, A rapid DNA isolation procedure for small quantities of fresh leaf tissue, Phytochemical Bulletin, 19: 11-15.
Department of Medical Science, Thai Herbal pharmacopoeia, 2016, KHAMIN CHAN: 145-151.
Sukati, S. and Khobjai, W., 2019, Total Phenolic Content and DPPH Free Radical Scavenging Activity of Young Turmeric Grown in Southern Thailand. In: URU International Conference on Science and Technology 2018. Trans Tech Publications Ltd: 61–69.
Kaewpiboon, C., Lirdprapamongkol, K., Srisomsap, C, Winayanuwattikun, P., Yongvanich, T. and Puwaprisirisan, P., 2012, Studies of the in vitro cytotoxic, antioxidant, lipase inhibitory and antimicrobial activities of selected Thai medicinal plants, BMC Comp. Altern. Med. 12:127.
Tanvir, E.M., Hossen, M.S., Hossain, M.F., izwana, A., Siew, H.G., Ibrahim, K. and Nurul, K., 2017, Antioxidant Properties of Popular Turmeric (Curcuma longa) Varieties from Bangladesh. J Food Qual: 8471785.
Du, Z.Y., Jiang, Y.F., Tang, Z.K., Mo, R.Q., Xue, G.H., Lu, Y.J., Zheng, X., Dong, C.Z. and Zhang, K., 2011, Antioxidation and tyrosinase inhibition of polyphenolic curcumin analogs. Biosci Biotechnol Biochem. ;75(12): 2351-8.
Maknoi, C., 2006, Taxonomy and Phylogeny of the Genus Curcuma L. (Zingiberaceae) with Particular Reference
to Its Occurrence in Thailand. Ph.D. Thesis, Prince of Songkla University, Thailand.
Tohda, C., Nakayama, N., Hatanaka, F. and Komatsu, K., 2006, Comparison of Anti-inflammatory Activities of Six Curcuma
Rhizomes: A Possible Curcuminoid-independent Pathway Mediated by Curcuma phaeocaulis Extract. Evidence-based
complementary and alternative medicine : eCAM, 3(2), 255–260.
Dosoky, N. S., Satyal, P. and Setzer, W.N., 2019, Variations in the Volatile Compositions of Curcuma Species. Foods (Basel, Switzerland), 8(2), 53.
Sandrasari, D.A., Sabariman, M. and Azni, I.N., 2019, Determination of potential level of Indonesian rhizomes as an antioxidant based on phenolic compound and antioxidant activity. IOP Conf Ser Earth Environ Sci 383:012017.
Mau, J.L., Eric, Y.C., Wang N.P., Chen, C.C., Chang, C.H. and Chyau, C.C., 2013, Composition and antioxidant activity of the essential oil from Curcuma zedoaria, Food Chemistry: 82(4): 583-591.
Akter, J., Islam, M.Z., Hossain, M.A. and Takara, K., 2021, Anti-tyrosinase properties of different species of turmeric and isolation of active compounds from Curcuma amada. Med Chem Res 30:1669–1676.
Lakshmi, S., Padmaja, G. and Remani, P., 2011, Antitumour Effects of Isocurcumenol Isolated from Curcuma zedoaria Rhizomes on Human and Murine Cancer Cells. International journal of medicinal chemistry: 253962.
