Development of Facial Cleansing Gel Containing Tri-kanpis Remedy Extract
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Abstract
The objective of this research is to study the phytochemical, and biological properties including antioxidant activity, antibacterial activity, and inhibition of tyrosinase enzyme in tri-kanpis remedy namely Ocimum tenuiflorum L., Boesenbergia rotunda (L.) Mansf., Alpinia galanga (L.) Willd. Additionally, it aims to develop facial cleansing gel products from the tri-kanpis remedies. Through the use of color formation reaction methods, various chemical substances were discovered, such as anthraquinones, cardiac glycosides, steroids, and terpenoids. The antioxidant activity was also studied, including the DPPH radical scavenging method, which showed an IC50 value of 555.94 µg/mL, and the ABTS radical cation decolorization method, which showed an IC50 value of 15.14 µg/mL. The antibacterial properties were studied using the agar well diffusion method, which found inhibitory effects against gram-positive bacteria: Staphylococcus aureus and Staphylococcus epidermidis, and gram-negative bacteria: Escherichia coli and Pseudomonas aeruginosa. The inhibition of the tyrosinase enzyme was studied using the dopachrome method, which revealed an IC50 value greater than 1000 µg/mL. According to initial studies on biological effectiveness, tri-kanpis remedy extracts have been included as components in a facial cleansing gel with a 1% concentration. This cleansing gel is characterized by its light brown color, transparency, and a pH level of 5.91, adhering to the established physical and chemical standards for facial cleansing products. As a result, there is potential for further development of this facial cleansing product within the industry in the future.
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