Effect of Coffee Ground Extract on Antioxidation, Inhibition of Alpha-Amylase and Lipase Activities, and Antiadipogenesis
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Abstract
Coffee ground is an organic waste from the coffee processing industry containing a number of bioactive compounds. This research aimed to investigate the effect of coffee ground extract on antioxidation, inhibition of alpha-amylase and lipase activities and antiadipogenesis. When the 70% ethanol extract of coffee ground was analyzed, it was found that the extract had total phenolic content and total flavonoid content of 50.54 ± 0.08 mg of gallic acid equivalent/g of extract and 5.03 ± 0.15 mg of quercetin equivalent/g of extract, respectively. It also exhibited antioxidant activity (IC50 = 171.18 ± 0.21 µg/mL) and inhibitory effect on alpha-amylase activity (IC50 = 152.71 ± 0.37 µg/mL) and lipase activity (IC50 = 131.08 ± 1.94 µg/mL). Furthermore, it was found to have antiadipogenic activity by reducing lipid accumulation in pre-adipocyte; hence, unable to develop into adipocyte. As a consequence of having antioxidant activity, inhibitory effect on alpha-amylase and lipase and antiadipogenic activity, the coffee ground extract has the potential to be further developed to anti-obesity agents.
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บทความที่ได้รับการตีพิมพ์เป็นลิขสิทธิ์ของ วารสารวิทยาศาสตร์และเทคโนโลยี มหาวิทยาลัยอุบลราชธานี
ข้อความที่ปรากฏในบทความแต่ละเรื่องในวารสารวิชาการเล่มนี้เป็นความคิดเห็นส่วนตัวของผู้เขียนแต่ละท่านไม่เกี่ยวข้องกับมหาวิทยาลัยอุบลราชธานี และคณาจารย์ท่านอื่นๆในมหาวิทยาลัยฯ แต่อย่างใด ความรับผิดชอบองค์ประกอบทั้งหมดของบทความแต่ละเรื่องเป็นของผู้เขียนแต่ละท่าน หากมีความผิดพลาดใดๆ ผู้เขียนแต่ละท่านจะรับผิดชอบบทความของตนเองแต่ผู้เดียว
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