Molecular Docking Simulation of Anti-tumor Necrosis Factor Alpha from Hemp Seed (Cannabis sativa L.)

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Published: Dec 2, 2020
Keywords:
Tumor necrosis factor alpha Inflammation Hemp seed Molecular docking

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Satapat Racha
Department of Pharmaceutical Chemistry and Natural Medicine, Faculty of Pharmacy, Payap University, Muang, Chiangmai 50000, Thailand
Kannika Racha
Department of Pharmacy Practice, Faculty of Pharmacy, Payap University, Muang, Chiangmai 50000, Thailand
Ekkapon Hirattanapun
Department of Pharmaceutical Care, Faculty of Pharmacy, Payap University, Muang, Chiangmai 50000, Thailand

Abstract

A pro-cytokine tumor necrosis factor alpha (TNF-alpha), is a novel potential target for treatment and prevention of immune-mediated inflammation. Potential anti-inflammatory activity of phenolamides from hemp seed have been reported, but the mechanism of action is unclear. Main aim of the study was to investigate the molecular interaction between five phenolamides and TNF-alpha by molecular docking. The results showed that coumaroylaminobutanol glucopyranoside is the most promising inhibitor of TNF-alpha. This finding provides
a better understanding of the molecular basis for the anti-inflammatory activity of hemp seed.

Article Details

How to Cite
Racha, S., Racha, K., & Hirattanapun, E. (2020). Molecular Docking Simulation of Anti-tumor Necrosis Factor Alpha from Hemp Seed (Cannabis sativa L.). YRU Journal of Science and Technology, 5(2), 132–140. retrieved from https://li01.tci-thaijo.org/index.php/yru_jst/article/view/241946
Issue
Vol. 5 No. 2 (2020): July-December
Section
Research Article

บทความ ข้อมูล เนื้อหา รูปภาพ ฯลฯ ที่ได้รับการเผยแพร่ในวารสารวิทยาศาสตร์และเทคโนโลยี มรย. นี้ ถือเป็นลิขสิทธิ์ของวารสารวิทยาศาสตร์และเทคโนโลยี มรย. หากบุคคลหรือหน่วยงานใดต้องการนำทั้งหมดหรือส่วนหนึ่งส่วนใดไปเผยแพร่ต่อหรือกระทำการใดๆ จะต้องได้รับอนุญาตเป็นลายลักษณ์อักษรจากวารสารวิทยาศาสตร์และเทคโนโลยี มรย. ก่อนเท่านั้น

Author Biography

Satapat Racha, Department of Pharmaceutical Chemistry and Natural Medicine, Faculty of Pharmacy, Payap University, Muang, Chiangmai 50000, Thailand

International Publication

Racha, S., Wongrattanakamon, P., Raiwa, A. et al. Discovery of Novel Potent Small Natural Molecules Able to Enhance Attenuation of the Pathobiology of Gastric Cancer-Associated Helicobacter pylori by Molecular Modeling. Int J Pept Res Ther 25, 881–896 (2019). https://doi.org/10.1007/s10989-018-9737-2

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