The Cultivation of a Blue Thai Marine Sponge, Xestospongia sp., under Natural Conditions to Produce Anticancer Compound, Renieramycin M การเลี้ยงฟองน้ำทะเลสีน้ำเงิน Xestospongia sp. ของไทยในสภาวะธรรมชาติเพื่อผลิตสารต้านมะเร็ง Renieramycin M
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Abstract
A Thai blue marine sponge, Xestospongia sp. (c.f. Neopetrosia sp.), can produce highly effective anticancer compounds; namely, Renieramycin M (RM). Currently, this compound is in clinical trials processes before developing it as a new anticancer agent. To provide sufficient RM for clinical trials and a prospective pharmaceutical market, a blue Xestospongia sponge was cultured under natural conditions to assess the RM production and record the growth. The sponge was cultured near the coastline of the Trang Province Sea area by the long line method for 10 months. Three substrates, i.e., a plastic rope, cement pieces, and a polyvinylchloride (PVC) pipe, respectively, were used. Results revealed that the sponge produced maximum and accumulated RM in September (0.42 µg/mg tissue), but it was not observed during summer (February-April) and the early monsoon season (May-July). The growth of a blue sponge did not exhibit any statistical difference at the 95% confidence interval. The maximum growth was observed in June. Based on the result, it can be concluded that changes in the temperature and salinity in the monsoon season cause the sponges to utilize its energy for synthesizing and accumulating RM in their tissues rather than utilizing for its growth.
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เนื้อหาและข้อมูลในบทความที่ลงตีพิมพ์ในวารสารวิชชา มหาวิทยาลัยราชภัฏนครศรีธรรมราช ถือเป็นข้อคิดเห็นและความรับผิดชอบของผู้เขียนบทความโดยตรง ซึ่งกองบรรณาธิการวารสารไม่จำเป็นต้องเห็นด้วยหรือร่วมรับผิดชอบใด ๆ
บทความ ข้อมูล เนื้อหา รูปภาพ ฯลฯ ที่ได้รับการตีพิมพ์ในวารสารวิชชา มหาวิทยาลัยราชภัฏนครศรีธรรมราช ถือเป็นลิขสิทธ์ของวารสารวิชชา มหาวิทยาลัยราชภัฏนครศรีธรรมราช หากบุคคลหรือหน่วยงานใดต้องการนำข้อมูลทั้งหมดหรือส่วนหนึ่งส่วนใดไปเผยแพร่ต่อหรือเพื่อการกระทำการใด ๆ จะต้องได้รับอนุญาตเป็นลายลักษณ์อักษรจากวารสารวิชชา มหาวิทยาลัยราชภัฏนครศรีธรรมราชก่อนเท่านั้น
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