Antimicrobial Activity of Copper Complexes and Carboxylic Acid Derivatives ฤทธิ์ยับยั้งเชื้อจุลินทรีย์ของสารประกอบเชิงซ้อนทองแดงและอนุพันธ์ของกรดคาร์บอกซิลิก

Abstract

The research studied the synthesis of two copper complexes; namely, (1) [Cu(H₂O)(PABA)₂] and (2) [Cu₂(tartaric)₂(H₂O)₂]•4H₂O. The substance structure were analyzed by X-ray diffraction technique on a single crystal. Basic functional groups were analyzed using infrared spectroscopy and the light absorption bands were studied by UV-Visible Spectroscopy. It was found that the complexes (1) had an orthorhombic crystal system. There were Pmc2 intersection groups and complexes (2) were monoclinic. There were P2₁ intersection groups. For basic function group analysis, it was found that the complexes (1) had functional groups O-H, N-H primary, C=O, C=C, C-N and C-H bending, and complexes (2) had functional groups O-H stretching, C-H stretching, carboxylic group stretching, C-O-C and Cu-O. The research studied the absorption bands of a substance at a wavelength of 200-800 nm. The absorbance bands of the substance were found at the maximum wavelengths of 231 and 740 nm. in the complexes (1). Besides, at maximum wavelengths equaled to 280 and 603 nm. in complex compounds (2). This was corresponded to electron transitions within ligand orbitals and electron transitions inside metal orbitals. Results from the study of the inhibitory efficacy and the lowest concentrations of the two complex compounds at the concentration of 80 mg/ml. With six microorganisms (Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumonia and Acinetobacter baumannii), it was found that both complexes had antimicrobial activity at a concentration equaled to 80 mg/ml.