Aqueous Extracts from Climbing Weeds with Antioxidants and Inhibitory Activities of Enzymes Related to Hyperglycemia and Obesity
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Abstract
Nowadays, some weeds are used as medicinal plants, because they contain phytochemicals that have been reported to have therapeutic effects on the human body. The aim of this study was to investigate the effects of water extracts from leaves of 9 climbing weeds including Passiflora foetida L., Oxystelma esculentum (L.f.) Sm., Ipomoea pes-tigridis L., Cardiospermum halicacabum L., Coccinia grandis (L.) Voigt, Centrosema pubescens Benth., Macroptilium atropurpureum (DC.) Urban, Momordica charantia L. and Ipomoea gracilis R.Br. on antioxidant properties (viz. DPPH, ABTS, NO radical scavenging and ox-LDL) and to determine the inhibitory activities on hyperglycemia- (viz. a-amylase and a-glucosidase) and obesity-related enzymes (viz. pancreatic lipase and 15-lipoxygenase). The results showed that the water extract from leaves of P. foetida, C. pubescens, M. charantia and C. halicacabum had the best antioxidant efficacy on DPPH·, ABTS·+, NO· and ox-LDL, respectively. Moreover, the extracts of all weeds showed a high ABTS·+ inhibitory effect of more than 79 %. In the case of inhibiting hyperglycemia- and obesity-related enzymatic activities, the water extract from leaves of C. grandis presented a high effect on inhibiting α-glucosidase and pancreatic lipase activities, while the water extract of C. halicacabum had a strong inhibitory activity of a-amylase. These results suggested that local weeds such as C. grandis, C. halicacabum, P. foetida, C. pubescens and M. charantia can be processed into food or herbal drinks. The identification of phytochemicals in the water extracts from leaves of these weeds need to be further conducted.
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