Biological Activity of Organic Flower Extract from Chrysanthemum indicum L. for Cosmetic Application
Keywords:
Chrysanthemum indicum, Bioactive compound, Antioxidant, cosmetic ingredientAbstract
Chrysanthemum indicum L. contains bioactive compounds and widely produced as herbal drink in Asia. The value added of C. indicum flowers as cosmetic product is still rarely studies. This research aimed to evaluate the bioactive compound of organic C. indicum flower and their biological activities for anti-aging. The dried C. indicum flower were extracted with water and examined for content of biological compounds. The extract was evaluated anti-aging properties such as anti-oxidant, collagenase and tyrosinase inhibition activities. The aqueous extract of C. indicum consisted of total phenolic, flavonoid and quercetin contents which found to be 72.28 mgGAE, 16.54 mgQE and 402.47 mg/kg, respectively. The antioxidant activities showed that C. indicum can be used as a potent antioxidant via ABTS, DPPH and superoxide scavenging activities. The half maximal inhibitory concentration (IC50) were 0.22, 0.32 and 9.39 mg/ml, respectively. Furthermore, the extract inhibited collagenase and tyrosinase activities which presented 2.33 and 102.11 mg/ml, respectively. From this study showed that aqueous extract of organic chrysanthemum flowers are bioactive substances asantioxidants and protection of skin damage. In addition, value added of C. indicum flowers as a functional ingredient or cosmetic ingredient are alternative products and income for farmers and cosmetics entrepreneurs.
References
Anitha, T. 2012. Medicinal plants used in skin protection. Asian J Pharm Clin Res. 5(2): 35-38.
Cheng, W., J. Li, T. You and C. Hu. 2005. Anti-inflammatory and immunomodulatory activities of the extracts from the inflorescence of Chrysanthemum indicum Linné. J Ethnopharmacol 101(1-3): 334-337.
Choi, M.H. and H.J. Shin. 2015. Anti-melanogenesis effect of quercetin. Cosmetics 3(2): 18.
Choi, K.T., J.H. Kim, H.T. Cho, S.S. Lim, S.S. Kwak and Y.J. Kim. 2016. Dermatologic evaluation of cosmetic formulations containing Chrysanthemum indicum extract. J Cosmet Dermatol. 15(2): 162-168.
Costa, R. and L. Santos. 2017. Delivery systems for cosmetics−from manufacturing to the skin of natural antioxidants. Powder Technol 322: 402-416.
D’Orazio, J., S. Jarrett, A. Amaro-Ortiz and T. Scott. 2013. UV radiation and the skin. Int J Mol Sci 14: 12222-12248.
Hammerschmidt, P.A. and D.E. Pratt. 1978. Phenolic antioxidants of dried soybeans. J Food Sci 43(2): 556-559.
Kanlayavattanakul, M. 2016. Herbs for Cosmetics: Anti-Wrinkle. Bangkok: Protexts Press. 118 p. [in Thai]
Kim, Y.J. 2012. Hyperin and quercetin modulate oxidative stress−induced melanogenesis. Biol Pharm Bull. 35(11): 2023-2027.
Kim, Y.J.. 2016. Extracts of Chrysanthemum indicum Linne mediated regulation of MMP1 via JNK−AP1 pathway. Asian J Beauty Cosmetol 14(4): 399-405.
Leelapornpisid, P., S. Chansakaow, S. Na-Boonlong and P. Jantrawut. 2014. Development of cream containing nanostructured lipid carriers loaded marigold (Tagetes erecta Linn) flowers extract for anti-wrinkles application. Int J Pharm Pharm Sci 6(5): 309-313.
Limtrakul, P., S. Yodkeeree, P. Thippraphan, W. Punfa and J. Srisomboon. 2016. Anti-aging and tyrosinase inhibition effects of Cassia fistula flower butanolic extract. BMC Complement Altern Med. 16: 497.
Malinowska, P. 2013. Effect of flavonoids content on antioxidant activity of commercial cosmetic plant extracts. Herba Pol. 59(3): 63-75.
Masuda, T., D. Yamashita, Y. Takeda and S. Yonemori. 2005. Screening for tyrosinase inhibitors among extracts of seashore plants and identification of potent inhibitors from Garcinia subelliptica. Biosci Biotechnol Biochem. 69(1): 197-201.
Mensor, L.L., F.S. Menezes, G.G. Leitão, A.S. Reis, T.C.D. Santos, C.S. Coube and S.G. Leitão. 2001. Screening of Brazilian plant extracts for antioxidant activity by the use of DPPH free radical method. Phytother Res 15(2): 127-130.
Nishikimi, M., N.A. Rao, K. Yagi. 1972. The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Biophy. Res Commun 46(2): 849-854.
Peñarrieta, J.M., J.A. Alvarado, B. Akesson and B. Bergenståhl. 2007. Separation of phenolic compounds from foods by reversed-phase high performance liquid chromatography. Revista Boliviana de Química 24(1): 1-4.
Rawdkhao, T. 2017. Production promotion of organic Chrysanthemum indicum L. 7 p. In Research Report. Chiang Mai: Maejo University. [in Thai]
Re, R., N. Pellegrini, A. Proteggente, A. Pannala, M. Yang and C. Rice-Evans. 1999. Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Radic Biol Med 26(9-10): 1231-1237.
Ribeiro, A.S., M. Estanqueiro, M.B. Oliveira and J.M.S. Lobo. 2015. Main benefits and applicability of plant extracts in skin care products. Cosmetics 2(2): 48-65.
Sasikumar, V. and P. Kalaisezhiyen. 2014. Evaluation of free radical scavenging activity of various leaf extracts from Kedrostis foetidissima (Jacq.) Cogn. Biochem Anal Biochem 3(2): 7.
Soto, M., E. Falqué and H. Domínguez. 2015. Relevance of natural phenolics from grape and derivative products in the formulation of cosmetics. Cosmetics 2(3): 259-276.
Stanković, M.S. 2011. Total phenolic content, flavonoid concentration and antioxidant activity of Marrubium peregrinum L. extracts. Kragujevac J. Sci 33: 63-72.
Tungmunnithum, D., A. Thongboonyou, A. Pholboon and A. Yangsabai. 2018. Flavonoids and other phenolic compounds from medicinal plants for pharmaceutical and medical aspects: an overview. Medicines 5(3): 93.
Whangsomnuek, N., L. Mungmai,K. Mengamphan and D. Amornlerdpison. 2019. Efficiency of skin whitening cream containing Etlingera elatior flower and leaf extracts in volunteers. Cosmetics 6(3): 39.
Zakiah, K., E. Anwar and T. Nurhayat. 2018. In-vitro evaluation of antioxidant activity and anti-collagenase activity of Thalassia hempricii as a potent ingredients for anti-wrinkle cosmetics. Pharmacogn J 10(4): 778-782.
Zolghadri, S., A. Bahrami, M.T.H. Khan, J. Munoz-Munoz, F. Garcia-Molina, F. Garcia-Canovas and A.A. Saboury. 2019. A comprehesive review on tyrosinase inhibitors. Enzyme Inhib Med. Chem 34(1): 279-309.
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